ID   SANA_ECO57              Reviewed;         239 AA.
AC   P0AFY4; P33017; P76438;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Protein SanA;
GN   Name=sanA; OrderedLocusNames=Z3399, ECs3036;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Participates in the barrier function of the cell envelope.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AE005174; AAG57282.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36459.1; -; Genomic_DNA.
DR   PIR; D91008; D91008.
DR   PIR; F85852; F85852.
DR   RefSeq; NP_311063.1; NC_002695.1.
DR   RefSeq; WP_000920064.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AFY4; -.
DR   STRING; 155864.EDL933_3305; -.
DR   PRIDE; P0AFY4; -.
DR   EnsemblBacteria; AAG57282; AAG57282; Z3399.
DR   EnsemblBacteria; BAB36459; BAB36459; ECs_3036.
DR   GeneID; 66673960; -.
DR   GeneID; 916740; -.
DR   KEGG; ece:Z3399; -.
DR   KEGG; ecs:ECs_3036; -.
DR   PATRIC; fig|386585.9.peg.3161; -.
DR   eggNOG; COG2949; Bacteria.
DR   HOGENOM; CLU_051474_0_2_6; -.
DR   OMA; YDEPDAM; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06259; YdcF-like; 1.
DR   InterPro; IPR003848; DUF218.
DR   InterPro; IPR023604; Uncharacterised_SanA.
DR   Pfam; PF02698; DUF218; 1.
DR   PIRSF; PIRSF005011; SanA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="Protein SanA"
FT                   /id="PRO_0000097578"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..239
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  27287 MW;  574EF9B02249547C CRC64;
     MLKRVFLSLL VLIGLLLLTV LGLDRWMSWK TAPYIYDELQ DLPYRQVGVV LGTAKYYRTG
     VINQYYRYRI QGAINAYNSG KVNYLLLSGD NALQSYNEPM TMRKDLIAAG VDPSDIVLDY
     AGFRTLDSIV RTRKVFDTND FIIITQRFHC ERALFIALHM GIQAQCYAVP SPKDMLSVRI
     REFAARFGAL ADLYIFKREP RFLGPLVPIP AMHQVPEDAQ GYPAVTPEQL LELQKKQGK