ID   SANA_ECOL6              Reviewed;         239 AA.
AC   P0AFY3; P33017; P76438;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Protein SanA;
GN   Name=sanA; OrderedLocusNames=c2677;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Participates in the barrier function of the cell envelope.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AE014075; AAN81133.1; -; Genomic_DNA.
DR   RefSeq; WP_000920064.1; NC_004431.1.
DR   AlphaFoldDB; P0AFY3; -.
DR   STRING; 199310.c2677; -.
DR   EnsemblBacteria; AAN81133; AAN81133; c2677.
DR   GeneID; 66673960; -.
DR   KEGG; ecc:c2677; -.
DR   eggNOG; COG2949; Bacteria.
DR   HOGENOM; CLU_051474_0_2_6; -.
DR   OMA; YDEPDAM; -.
DR   BioCyc; ECOL199310:C2677-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06259; YdcF-like; 1.
DR   InterPro; IPR003848; DUF218.
DR   InterPro; IPR023604; Uncharacterised_SanA.
DR   Pfam; PF02698; DUF218; 1.
DR   PIRSF; PIRSF005011; SanA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="Protein SanA"
FT                   /id="PRO_0000097577"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..239
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  27287 MW;  574EF9B02249547C CRC64;
     MLKRVFLSLL VLIGLLLLTV LGLDRWMSWK TAPYIYDELQ DLPYRQVGVV LGTAKYYRTG
     VINQYYRYRI QGAINAYNSG KVNYLLLSGD NALQSYNEPM TMRKDLIAAG VDPSDIVLDY
     AGFRTLDSIV RTRKVFDTND FIIITQRFHC ERALFIALHM GIQAQCYAVP SPKDMLSVRI
     REFAARFGAL ADLYIFKREP RFLGPLVPIP AMHQVPEDAQ GYPAVTPEQL LELQKKQGK