SANA_SHIFL
ID SANA_SHIFL Reviewed; 239 AA.
AC P0AFY5; P33017; P76438;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Protein SanA;
GN Name=sanA; OrderedLocusNames=SF2229, S2358;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Participates in the barrier function of the cell envelope.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}.
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DR EMBL; AE005674; AAN43751.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP17568.1; -; Genomic_DNA.
DR RefSeq; NP_708044.2; NC_004337.2.
DR RefSeq; WP_000920064.1; NZ_WPGW01000017.1.
DR AlphaFoldDB; P0AFY5; -.
DR STRING; 198214.SF2229; -.
DR EnsemblBacteria; AAN43751; AAN43751; SF2229.
DR EnsemblBacteria; AAP17568; AAP17568; S2358.
DR GeneID; 1026730; -.
DR GeneID; 66673960; -.
DR KEGG; sfl:SF2229; -.
DR KEGG; sfx:S2358; -.
DR PATRIC; fig|198214.7.peg.2670; -.
DR HOGENOM; CLU_051474_0_2_6; -.
DR OrthoDB; 1879123at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd06259; YdcF-like; 1.
DR InterPro; IPR003848; DUF218.
DR InterPro; IPR023604; Uncharacterised_SanA.
DR Pfam; PF02698; DUF218; 1.
DR PIRSF; PIRSF005011; SanA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..239
FT /note="Protein SanA"
FT /id="PRO_0000097579"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..239
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 189
FT /note="A -> T (in Ref. 2; AAP17568)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 27287 MW; 574EF9B02249547C CRC64;
MLKRVFLSLL VLIGLLLLTV LGLDRWMSWK TAPYIYDELQ DLPYRQVGVV LGTAKYYRTG
VINQYYRYRI QGAINAYNSG KVNYLLLSGD NALQSYNEPM TMRKDLIAAG VDPSDIVLDY
AGFRTLDSIV RTRKVFDTND FIIITQRFHC ERALFIALHM GIQAQCYAVP SPKDMLSVRI
REFAARFGAL ADLYIFKREP RFLGPLVPIP AMHQVPEDAQ GYPAVTPEQL LELQKKQGK
