ID   SANBR_RAT               Reviewed;         737 AA.
AC   A1A5R8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=SANT and BTB domain regulator of class switch recombination {ECO:0000250|UniProtKB:Q6NSI8};
DE            Short=SANT and BTB domain regulator of CSR;
GN   Name=Sanbr {ECO:0000250|UniProtKB:Q6NSI8};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Negatively regulates class switch recombination or isotype
CC       switching in splenic B-cells. {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- SUBUNIT: Homodimer. Interacts (via the BTB domain) with HDAC1 and
CC       NCOR2. {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- DOMAIN: The BTB domain is important for homodimerization and for its
CC       function in negative regulation of class switch recombination.
CC       {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- SIMILARITY: Belongs to the KIAA1841 family. {ECO:0000305}.
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DR   EMBL; BC128776; AAI28777.1; -; mRNA.
DR   RefSeq; NP_001094441.1; NM_001100971.1.
DR   AlphaFoldDB; A1A5R8; -.
DR   SMR; A1A5R8; -.
DR   STRING; 10116.ENSRNOP00000007385; -.
DR   PaxDb; A1A5R8; -.
DR   PRIDE; A1A5R8; -.
DR   Ensembl; ENSRNOT00000085886; ENSRNOP00000074352; ENSRNOG00000054669.
DR   GeneID; 305579; -.
DR   KEGG; rno:305579; -.
DR   UCSC; RGD:1305110; rat.
DR   CTD; 84542; -.
DR   RGD; 1305110; RGD1305110.
DR   eggNOG; ENOG502QRE4; Eukaryota.
DR   GeneTree; ENSGT00390000008178; -.
DR   InParanoid; A1A5R8; -.
DR   OMA; ECAKRFE; -.
DR   OrthoDB; 904755at2759; -.
DR   PhylomeDB; A1A5R8; -.
DR   TreeFam; TF324503; -.
DR   PRO; PR:A1A5R8; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000054669; Expressed in cerebellum and 19 other tissues.
DR   ExpressionAtlas; A1A5R8; baseline and differential.
DR   Genevisible; A1A5R8; RN.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
DR   CDD; cd00167; SANT; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR045902; SANBR-like.
DR   InterPro; IPR021777; SANBR_BTB.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR20946; PTHR20946; 1.
DR   Pfam; PF11822; DUF3342; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..737
FT                   /note="SANT and BTB domain regulator of class switch
FT                   recombination"
FT                   /id="PRO_0000324600"
FT   DOMAIN          21..59
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   DOMAIN          147..255
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REGION          555..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   737 AA;  84345 MW;  ECE522D63DAF1CE6 CRC64;
     MSRGCPENNN FLTNNNQMVL DMILYPLIGI PQTINWETVA RLVPGLTPKE CVKRFDELKS
     CGSSPVDNQY NPLMAAGEGP VETLATYIKS SLLDAQGDFQ ETPVDQDTVS KAGRHSIATT
     RNCSSESENC TARNAGEETG DSEGPNMVIH VCDEAKSLKE DFICPRDLLI SEMKYFAEYL
     SVDAQRWEEV DISVHCDVHI FNWLIKYVKR NTKDSKDCEL PALEPGNVIS ILISSEFLKM
     DSLVEQCIQY CHKNMNAIVA APCNMNCINV NLLTRIADLF THNEIDDLKD KKDKFRSKLF
     CKKIERLFDP EYFNPDSRNN AATLYRCCLC KKLLTRETER RISCIPGKIN VDRHGNIIYI
     HIRDKTWDVH EYLNSLFEEL KSWRDVYWRL WGTINWLTCS RCYQAFLCIE FSHCQYHSEV
     VVYSSAVNSL NTVGTGIYPC CNQKVLRFDP TQLTKGCKVR DHMVLLHDQG ENDDSLSCPT
     AKILDDLHKH KDVIAVPFLK DPVSDPGVGS CDEKGLEYEI LLEPNTPWGS KTGELNAFLS
     LKNWTLQLKQ QSLFSEEEEY TTGSEVTEDE VGDEEEISKK QRKKEKPKKF TKPPKKQLSS
     PCSQKKEKTL EKSTSRDVSP FVVSMQKNKW DATRSLRFNQ DAQREDDQRR MSEITGHLIK
     MRLGDLDRVK AKESKEFAGG IYSRLEAQVK ASVPVTARQN SSDKNQSNIP QRHLFNYVHS
     NFIRNSQKLE TSQMFIN