ID   SANBR_XENLA             Reviewed;         715 AA.
AC   Q08AX9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=SANT and BTB domain regulator of class switch recombination {ECO:0000250|UniProtKB:Q6NSI8};
DE            Short=SANT and BTB domain regulator of CSR;
GN   Name=sanbr {ECO:0000250|UniProtKB:Q6NSI8};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates class switch recombination or isotype
CC       switching in splenic B-cells. {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- DOMAIN: The BTB domain is important for homodimerization and for its
CC       function in negative regulation of class switch recombination.
CC       {ECO:0000250|UniProtKB:Q68FF0}.
CC   -!- SIMILARITY: Belongs to the KIAA1841 family. {ECO:0000305}.
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DR   EMBL; BC124960; AAI24961.1; -; mRNA.
DR   RefSeq; NP_001121306.1; NM_001127834.1.
DR   AlphaFoldDB; Q08AX9; -.
DR   SMR; Q08AX9; -.
DR   DNASU; 100158390; -.
DR   GeneID; 100158390; -.
DR   KEGG; xla:100158390; -.
DR   CTD; 100158390; -.
DR   Xenbase; XB-GENE-993257; sanbr.L.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 100158390; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0045190; P:isotype switching; ISS:UniProtKB.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR045902; SANBR-like.
DR   InterPro; IPR021777; SANBR_BTB.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR20946; PTHR20946; 1.
DR   Pfam; PF11822; DUF3342; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..715
FT                   /note="SANT and BTB domain regulator of class switch
FT                   recombination"
FT                   /id="PRO_0000324601"
FT   DOMAIN          21..59
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   DOMAIN          146..254
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REGION          552..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          689..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..600
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  80552 MW;  1A496DDAFA57F2F6 CRC64;
     MSHRYSENNN FPYDNNQMVL DMILCSLVGV PQPISWDSVA RLVPGYTPKE CAKRFEELKS
     SGTSPVDNQY NPLMATGGIP LESLASYIKS SLLDPVDDQE DVTVGQGTIS IIGRPGATTA
     RKCSESDRCS SSLKGDSTTG SQGPNMVIHV CDEAKNLKED FVCPRDLLVS EMKYFAEYLS
     TDAQRCEEVD ISVHCDVHIF DWLMRYVKRS APENENQEIP KLEPGNVISI LISSEFLKME
     SLVEECIRYC HKNMSAIVAT PCNMNCINAN LLTRIANLFT HNEADDVKDK KDKFKSKIFC
     KKIERLFDAE CKNADSPANA STLFRCCLCK RLLTKEAEKK IDCLPGRISI DQHGNIVYLH
     IRDKSWDVHE YLISLFEELK SWRDVYWRLW GTINWLTCSR CKQSFLCNES SHCQYHPEPA
     VYPGAASSLD SPGTGIYPCC NQKVLRFDPA QLPKGCKVRD HVVGLPGGGD NMSENPSCNF
     LSDLLQRRDV IAVPFSKDLN GDSGIVLSEE PSFKCDALLE PNTLYGQKTG EMNAFLSLKN
     ISLQLKQQSL LSEEEDYTTG SEVTEDEVGD EEELSRKQAG RKVKPKRSAK QTKKHISSPS
     IHKKERQQEK ASRDSSPFTV SLQRNKWDAS RSLRFNQDAQ REDDQRRMTE ITGHLIKIRL
     GDLERVKAKE GKEQAGGIYA RLEAQIKASA HSNTRQMNTE KIPRPKPRFG TGRPT