ID   SANS_VACCC              Reviewed;         353 AA.
AC   P21077;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 105.
DE   RecName: Full=Surface antigen S;
DE            Short=S antigen;
DE   Flags: Precursor;
GN   ORFNames=B19R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: May bind interleukin-1 and/or interleukin-6 and prevent these
CC       cytokines reaching their natural receptors. In consequence the
CC       inflammatory response would be diminished and virus replication
CC       enhanced.
CC   -!- SUBCELLULAR LOCATION: Host cell surface. Note=Induced on the surface of
CC       vaccinia virus-infected cells.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48218.1; -; Genomic_DNA.
DR   PIR; I42527; SAVZVC.
DR   SMR; P21077; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR013151; Immunoglobulin.
DR   PANTHER; PTHR11890; PTHR11890; 1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Early protein; Glycoprotein; Immunoglobulin domain;
KW   Reference proteome; Repeat; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..353
FT                   /note="Surface antigen S"
FT                   /id="PRO_0000015465"
FT   DOMAIN          67..139
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          157..239
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          248..347
FT                   /note="Ig-like V-type"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        263
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        323
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        75..131
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        174..223
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        274..335
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   353 AA;  40952 MW;  51BF8080CDE1A224 CRC64;
     MTMKMMVHIY FVSLSLLLLL FHSYAIDIEN EITEFFNKMR DTLPAKDSKW LNPACMFGGT
     MNDMATLGEP FSAKCPPIED SLLSHRYKDY VVKWERLEKN RRRQVSNKRV KHGDLWIANY
     TSKFSNRRYL CTVTTKNGDC VQGIVRSHIK KPPSCIPKTY ELGTHDKYGI DLYCGILYAK
     HYNNITWYKD NKEINIDDIK YSQTGKELII HNPELEDSGR YDCYVHYDDV RIKNDIVVSR
     CKILTVIPSQ DHRFKLILDP KINVTIGEPA NITCTAVSTS LLIDDVLIEW ENPSGWLIGF
     DFDVYSVLTS RGGITEATLY FENVTEEYIG NTYKCRGHNY YFEKTLTTTV VLE