ID   SANS_VACCD              Reviewed;         351 AA.
AC   P23998;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   12-AUG-2020, entry version 92.
DE   RecName: Full=Surface antigen S;
DE            Short=S antigen;
DE   Flags: Precursor;
GN   ORFNames=B19R;
OS   Vaccinia virus (strain Dairen I) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10250;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2196742; DOI=10.1016/0042-6822(90)90524-u;
RA   Ueda Y., Morikawa S., Matsuura Y.;
RT   "Identification and nucleotide sequence of the gene encoding a surface
RT   antigen induced by vaccinia virus.";
RL   Virology 177:588-594(1990).
CC   -!- FUNCTION: May bind interleukin-1 and/or interleukin-6 and prevent these
CC       cytokines reaching their natural receptors. In consequence the
CC       inflammatory response would be diminished and virus replication
CC       enhanced.
CC   -!- SUBCELLULAR LOCATION: Host cell surface. Note=Induced on the surface of
CC       vaccinia virus-infected cells.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D90076; BAA14116.1; -; Genomic_DNA.
DR   PIR; A35522; SAVZVV.
DR   SMR; P23998; -.
DR   GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR013151; Immunoglobulin.
DR   PANTHER; PTHR11890; PTHR11890; 1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Early protein; Glycoprotein; Immunoglobulin domain; Repeat;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..351
FT                   /note="Surface antigen S"
FT                   /id="PRO_0000015466"
FT   DOMAIN          65..137
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          155..237
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          246..345
FT                   /note="Ig-like V-type"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        182
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        321
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        73..129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        172..221
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        272..333
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   351 AA;  40702 MW;  20997CB67D39E7DB CRC64;
     MTMKMMVHIY FVSLLLLLFH SYAIDIENEI TEFFNKMRDT LPAKDSKWLN PACMFGGTMN
     DIAALGEPFS AKCPPIEDSL LSHRYKDYVV KWERLEKNRR RQVSNKRVKH GDLWIANYTS
     KFSNRRYLCT VTTKNGDCVQ GIVRSHIKKP PSCIPKTYEL GTHDKYGIDL YCGILYAKHY
     NNITWYKDNK EINIDDIKYS QTGKKLIIHN PELEDSGRYN CYVHYDDVRI KNDIVVSRCK
     ILTVIPSQDH RFKLILDPKI NVTIGEPANI TCTAVSTSLL IDDVLIEWEN PSGWLIGFDF
     DVYSVLTSRG GITEATLYFE NVTEEYIGNT YKCRGHNYYF EKTLTTTVVL E