SANT_PLAF7
ID SANT_PLAF7 Reviewed; 585 AA.
AC Q03400; A0A143ZZC7; Q8IJ57;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=S-antigen protein;
DE Flags: Precursor;
GN ORFNames=PF10_0343, PF3D7_1035200;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1474992; DOI=10.1016/0166-6851(92)90161-c;
RA Bickle Q.D., Coppel R.;
RT "A fourth family of the Plasmodium falciparum S-antigen.";
RL Mol. Biochem. Parasitol. 56:141-150(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
CC -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC sera of some infected individuals. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Parasitophorous vacuole
CC {ECO:0000250|UniProtKB:P04927}. Note=Localizes to the cell periphery in
CC early schizonts and then to the parasitophorous vacuole in late
CC schizonts. Following schizont rupture, the S-antigen is released in
CC host sera. {ECO:0000250|UniProtKB:P04927}.
CC -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC the repetitive regions. {ECO:0000305|PubMed:1474992}.
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DR EMBL; M81799; AAA29761.1; -; mRNA.
DR EMBL; LN999944; CZT98609.1; -; Genomic_DNA.
DR PIR; A48459; A48459.
DR RefSeq; XP_001347627.1; XM_001347591.1.
DR AlphaFoldDB; Q03400; -.
DR SMR; Q03400; -.
DR STRING; 5833.PF10_0343; -.
DR PRIDE; Q03400; -.
DR EnsemblProtists; CZT98609; CZT98609; PF3D7_1035200.
DR GeneID; 810500; -.
DR KEGG; pfa:PF3D7_1035200; -.
DR VEuPathDB; PlasmoDB:PF3D7_1035200; -.
DR HOGENOM; CLU_466535_0_0_1; -.
DR InParanoid; Q03400; -.
DR OMA; PEGQEQC; -.
DR PhylomeDB; Q03400; -.
DR Proteomes; UP000001450; Chromosome 10.
DR GO; GO:0020003; C:symbiont-containing vacuole; TAS:GeneDB.
DR InterPro; IPR008825; S-antigen.
DR Pfam; PF05756; S-antigen; 1.
PE 2: Evidence at transcript level;
KW Malaria; Reference proteome; Repeat; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..585
FT /note="S-antigen protein"
FT /id="PRO_0000024626"
FT REPEAT 102..109
FT /note="1"
FT REPEAT 110..117
FT /note="2"
FT REPEAT 118..125
FT /note="3"
FT REPEAT 126..133
FT /note="4"
FT REPEAT 134..141
FT /note="5"
FT REPEAT 142..149
FT /note="6"
FT REPEAT 150..157
FT /note="7"
FT REPEAT 158..165
FT /note="8"
FT REPEAT 166..173
FT /note="9"
FT REPEAT 174..181
FT /note="10"
FT REPEAT 182..189
FT /note="11"
FT REPEAT 190..197
FT /note="12"
FT REPEAT 198..205
FT /note="13"
FT REPEAT 206..213
FT /note="14"
FT REPEAT 214..221
FT /note="15"
FT REPEAT 222..229
FT /note="16"
FT REPEAT 230..237
FT /note="17"
FT REPEAT 238..245
FT /note="18"
FT REPEAT 246..253
FT /note="19"
FT REPEAT 254..261
FT /note="20"
FT REPEAT 262..269
FT /note="21"
FT REPEAT 270..277
FT /note="22"
FT REPEAT 278..285
FT /note="23"
FT REPEAT 286..293
FT /note="24"
FT REPEAT 294..301
FT /note="25"
FT REPEAT 302..309
FT /note="26"
FT REPEAT 310..317
FT /note="27"
FT REPEAT 318..325
FT /note="28"
FT REPEAT 326..333
FT /note="29"
FT REPEAT 334..341
FT /note="30"
FT REPEAT 342..349
FT /note="31"
FT REPEAT 350..357
FT /note="32"
FT REPEAT 358..365
FT /note="33"
FT REPEAT 366..373
FT /note="34"
FT REPEAT 374..381
FT /note="35"
FT REPEAT 382..389
FT /note="36"
FT REPEAT 390..397
FT /note="37"
FT REPEAT 398..405
FT /note="38"
FT REPEAT 406..413
FT /note="39"
FT REPEAT 414..421
FT /note="40"
FT REPEAT 422..429
FT /note="41"
FT REPEAT 430..437
FT /note="42"
FT REPEAT 438..445
FT /note="43"
FT REPEAT 446..453
FT /note="44"
FT REPEAT 454..461
FT /note="45"
FT REPEAT 462..469
FT /note="46"
FT REPEAT 470..477
FT /note="47"
FT REPEAT 478..485
FT /note="48"
FT REPEAT 486..493
FT /note="49"
FT REPEAT 494..501
FT /note="50"
FT REPEAT 502..509
FT /note="51"
FT REPEAT 510..517
FT /note="52"
FT REPEAT 518..525
FT /note="53"
FT REPEAT 526..533
FT /note="54"
FT REPEAT 534..541
FT /note="55"
FT REPEAT 542..549
FT /note="56"
FT REGION 51..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..549
FT /note="56 X 8 AA tandem repeats of E-D-[EK]-V-S-N-G-[RG]"
FT COMPBIAS 62..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 101
FT /note="S -> T (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 456
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 536
FT /note="K -> E (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="D -> DEVSNGRED (in Ref. 1; AAA29761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 585 AA; 62947 MW; 318A9ABB83711A28 CRC64;
MNRILSVTLC LFFIYLYIYK TYGKVKNTDE GLSNIYGAKY YLRSGLFNEK NGKGQKYEDL
EEEKEGENDD EEDSNSEESN NDEENELIKG QEGVEQETHG SEDEVSNGRE DKVSNGGEDE
VSNGGEDEVS NGREDKVSNG GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGGEDEVSNG
REDKVSNGGE DEVSNGREDK VSNGREDKVS NGGEDEVSNG REDKVSNGRE DKVSNGGEDE
VSNGREDKVS NGGEDEVSNG REDKVSNGGE DEVSNGREDK VSNGREDEVS NGREDKVSNG
GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG GEDEVSNGRE DKVSNGGEDE
VSNGREDKVS NGREDKVSNG REDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG
GEDEVSNGRE DKVSNGGEDE VSNGREDKVS NGREDKVSNG REDKVSNGGE DEVSNGGEDE
VSNGREDKVS NGGEDEVSNG REDKVSNGGE DEVSNGREDK VSNGGEDEVS NGREDKVSNG
REDEVSNGRE DKGGAGTDGE LSHNSESHTK NKKSKNSIIN MLIGM
