ID   SANT_PLAFF              Reviewed;         265 AA.
AC   P04927;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=S-antigen protein;
DE   Flags: Precursor;
OS   Plasmodium falciparum (isolate FC27 / Papua New Guinea).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3886159; DOI=10.1016/0092-8674(85)90337-x;
RA   Cowman A.F., Saint R.B., Coppel R.L., Brown G.V., Anders R.F., Kemp D.J.;
RT   "Conserved sequences flank variable tandem repeats in two S-antigen genes
RT   of Plasmodium falciparum.";
RL   Cell 40:775-783(1985).
RN   [2]
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=2406433; DOI=10.1111/j.1550-7408.1990.tb01117.x;
RA   Culvenor J.G., Crewther P.E.;
RT   "S-antigen localization in the erythrocytic stages of Plasmodium
RT   falciparum.";
RL   J. Protozool. 37:59-65(1990).
CC   -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC       sera of some infected individuals. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Parasitophorous vacuole
CC       {ECO:0000269|PubMed:2406433}. Note=Localizes to the cell periphery in
CC       early schizonts and then to the parasitophorous vacuole in late
CC       schizonts (PubMed:2406433). Following schizont rupture, the S-antigen
CC       is released in host sera (PubMed:2406433).
CC       {ECO:0000269|PubMed:2406433}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during the parasite blood stage,
CC       specifically in schizonts (at protein level) (PubMed:2406433). Not
CC       expressed in free merozoites (at protein level) (PubMed:2406433).
CC       {ECO:0000269|PubMed:2406433}.
CC   -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC       the repetitive regions. {ECO:0000305|PubMed:3886159}.
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DR   EMBL; M10129; AAA29757.1; -; Genomic_DNA.
DR   PIR; A22011; YAZQF7.
DR   AlphaFoldDB; P04927; -.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IDA:UniProtKB.
DR   InterPro; IPR008825; S-antigen.
DR   Pfam; PF05756; S-antigen; 1.
PE   1: Evidence at protein level;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..265
FT                   /note="S-antigen protein"
FT                   /id="PRO_0000024622"
FT   REPEAT          97..107
FT                   /note="1"
FT   REPEAT          108..118
FT                   /note="2"
FT   REPEAT          119..129
FT                   /note="3"
FT   REPEAT          130..140
FT                   /note="4"
FT   REPEAT          141..151
FT                   /note="5"
FT   REPEAT          152..162
FT                   /note="6"
FT   REPEAT          163..173
FT                   /note="7"
FT   REPEAT          174..184
FT                   /note="8"
FT   REPEAT          185..195
FT                   /note="9"
FT   REPEAT          196..206
FT                   /note="10"
FT   REPEAT          207..217
FT                   /note="11"
FT   REPEAT          218..228
FT                   /note="12"
FT   REPEAT          229..239
FT                   /note="13; approximate"
FT   REGION          59..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..239
FT                   /note="13 X 11 AA approximate tandem repeats of P-A-K-A-S-
FT                   Q-G-G-L-E-D"
FT   COMPBIAS        64..90
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  27934 MW;  D7C34A2CA0E997CA CRC64;
     MNRILSVTFY LFFIYLYIYE TYGKVKNTDK ELSDIYGTKY YLRSGFFNSK KCKGHKYEDL
     QAEGEGENDK EEDSNNEEMN IDEENGLIEG QGESEDPAKA SQGGLEDPAK ASQGGLEDPA
     KASQGGLEDP AKASQGGLED PAKASQGGLE DPAKASQGGL EDPAKASQGG LEDPAKASQG
     GLEDPAKASQ GGLEDPAKAS QGGLEDPAKA SQGGLEDPAK ASQGGLEDPA KASQGGAEGH
     GKHAPNKENK NKNKESIKNI MNMFI