ID   SANT_PLAFN              Reviewed;         309 AA.
AC   P04928;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=S-antigen protein;
DE   Flags: Precursor;
OS   Plasmodium falciparum (isolate NF7 / Ghana).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5842;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3886159; DOI=10.1016/0092-8674(85)90337-x;
RA   Cowman A.F., Saint R.B., Coppel R.L., Brown G.V., Anders R.F., Kemp D.J.;
RT   "Conserved sequences flank variable tandem repeats in two S-antigen genes
RT   of Plasmodium falciparum.";
RL   Cell 40:775-783(1985).
CC   -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC       sera of some infected individuals. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Parasitophorous vacuole
CC       {ECO:0000250|UniProtKB:P04927}. Note=Localizes to the cell periphery in
CC       early schizonts and then to the parasitophorous vacuole in late
CC       schizonts. Following schizont rupture, the S-antigen is released in
CC       host sera. {ECO:0000250|UniProtKB:P04927}.
CC   -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC       the repetitive regions. {ECO:0000305|PubMed:3886159}.
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DR   EMBL; M10130; AAA29758.1; -; Genomic_DNA.
DR   PIR; B22011; YAZQN7.
DR   AlphaFoldDB; P04928; -.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008825; S-antigen.
DR   Pfam; PF05756; S-antigen; 1.
PE   3: Inferred from homology;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..309
FT                   /note="S-antigen protein"
FT                   /id="PRO_0000024623"
FT   REPEAT          257..271
FT                   /note="15-1"
FT   REPEAT          272..286
FT                   /note="15-2"
FT   REGION          52..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..256
FT                   /note="20 X 8 AA approximate tandem repeats of A-[RL]-K-S-
FT                   D-E-A-E"
FT   REGION          257..286
FT                   /note="2 X 15 AA tandem repeats of S-E-A-G-T-E-G-P-K-G-T-G-
FT                   G-P-G"
FT   COMPBIAS        62..88
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  33695 MW;  63574C51D62024FC CRC64;
     MNRILSVSFY LFFLYLYIYK TYGKVKNTDQ EISNIYGTNY YLRNGFLNGK NGKGNKYEDL
     QEEGEGENDD EEHSNSEESD NDEENEIIVG QDEAPKSDEA EALKSDEAEA LKSDEAEARK
     SDEAEALKSD EAEARKSDEA EALKSDEAEA LKSDEAEARK SDEAEALKSD EAEALKSDEA
     EARKSDEAEA RKSDEAEARK SDEAEARKSD EAEALKSDEA EARKSDEAEA RKSDEAEALK
     SDEAEARKSD EAEARKSEAG TEGPKGTGGP GSEAGTEGPK GTGGPGSGGE HSHNKKKSKK
     SIMNMLILM