ID   SANT_PLAFV              Reviewed;         375 AA.
AC   P09593;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=S-antigen protein;
DE   Flags: Precursor;
OS   Plasmodium falciparum (isolate v1).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3325726;
RA   Brown H., Kemp D.J., Barzaga N., Brown G.V., Anders R.F., Coppel R.L.;
RT   "Sequence variation in S-antigen genes of Plasmodium falciparum.";
RL   Mol. Biol. Med. 4:365-376(1987).
CC   -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC       sera of some infected individuals. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Parasitophorous vacuole
CC       {ECO:0000250|UniProtKB:P04927}. Note=Localizes to the cell periphery in
CC       early schizonts and then to the parasitophorous vacuole in late
CC       schizonts. Following schizont rupture, the S-antigen is released in
CC       host sera. {ECO:0000250|UniProtKB:P04927}.
CC   -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC       the repetitive regions. {ECO:0000305|PubMed:3325726}.
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DR   EMBL; M19155; AAA29472.1; -; Genomic_DNA.
DR   PIR; JS0427; JS0427.
DR   AlphaFoldDB; P09593; -.
DR   GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008825; S-antigen.
DR   Pfam; PF05756; S-antigen; 1.
PE   3: Inferred from homology;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..375
FT                   /note="S-antigen protein"
FT                   /id="PRO_0000024624"
FT   REPEAT          105..115
FT                   /note="1"
FT   REPEAT          116..126
FT                   /note="2"
FT   REPEAT          127..137
FT                   /note="3"
FT   REPEAT          138..148
FT                   /note="4"
FT   REPEAT          149..159
FT                   /note="5"
FT   REPEAT          160..170
FT                   /note="6"
FT   REPEAT          171..181
FT                   /note="7"
FT   REPEAT          182..192
FT                   /note="8"
FT   REPEAT          193..203
FT                   /note="9"
FT   REPEAT          204..214
FT                   /note="10"
FT   REPEAT          215..225
FT                   /note="11"
FT   REPEAT          226..236
FT                   /note="12"
FT   REPEAT          237..247
FT                   /note="13"
FT   REPEAT          248..258
FT                   /note="14"
FT   REPEAT          259..269
FT                   /note="15"
FT   REPEAT          270..280
FT                   /note="16"
FT   REPEAT          281..291
FT                   /note="17; approximate"
FT   REPEAT          292..302
FT                   /note="18"
FT   REPEAT          303..313
FT                   /note="19"
FT   REGION          47..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..313
FT                   /note="19 X 11 AA approximate tandem repeats of G-G-P-G-S-
FT                   E-G-P-K-G-T"
FT   COMPBIAS        62..90
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  35500 MW;  B6CA3342AC279BD2 CRC64;
     MNRILSVSFY LFFLYLYIYK TYGKVKNTDQ EISNIYGTNY YLRNGFLNGK NGKGNKYEDL
     QEEGEGENDD EEHSNSEESD NDEENEIIVG QDGSDQEVKV QKEQGGPGSE GPKGTGGPGS
     EGPKGTGGPG SEGPKGTGGP GSEGPKGTGG PGSEGPKGTG GPGSEGPKGT GGPGSEGPKG
     TGGPGSEGPK GTGGPGSEGP KGTGGPGSEG PKGTGGPGSE GPKGTGGPGS EGPKGTGGPG
     SEGPKGTGGP GSEGPKGTGG PGSEGPKGTG GPGSEGPKGT GGPGSESPKG TGGPGSEGPK
     GTGGPGSEGP KGTGPKGTGG PGSEAGTEGP KGTGGPGSEA GTEGPKGTGG PGSGGEHSHN
     KKKSKKSIMN MLIGV