SANT_PLAFW
ID SANT_PLAFW Reviewed; 640 AA.
AC P13821;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=S-antigen protein;
DE Flags: Precursor;
OS Plasmodium falciparum (isolate Wellcome).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5848;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2836730; DOI=10.1016/0166-6851(88)90174-0;
RA Nicholls S.C., Hillman Y., Lockyer M.J., Odink K.G., Holder A.A.;
RT "An S antigen gene from Plasmodium falciparum contains a novel repetitive
RT sequence.";
RL Mol. Biochem. Parasitol. 28:11-20(1988).
CC -!- FUNCTION: S antigens are soluble heat-stable proteins present in the
CC sera of some infected individuals. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Parasitophorous vacuole
CC {ECO:0000250|UniProtKB:P04927}. Note=Localizes to the cell periphery in
CC early schizonts and then to the parasitophorous vacuole in late
CC schizonts. Following schizont rupture, the S-antigen is released in
CC host sera. {ECO:0000250|UniProtKB:P04927}.
CC -!- POLYMORPHISM: Diversity in S-antigen is mainly due to polymorphism in
CC the repetitive regions. {ECO:0000305|PubMed:2836730}.
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DR EMBL; M18824; AAA29760.1; -; Genomic_DNA.
DR PIR; A54502; A54502.
DR AlphaFoldDB; P13821; -.
DR GO; GO:0020003; C:symbiont-containing vacuole; IEA:UniProtKB-SubCell.
DR InterPro; IPR008825; S-antigen.
DR Pfam; PF05756; S-antigen; 1.
PE 3: Inferred from homology;
KW Malaria; Repeat; Signal.
FT SIGNAL 1..23
FT CHAIN 24..640
FT /note="S-antigen protein"
FT /id="PRO_0000024625"
FT REPEAT 90..97
FT /note="1"
FT REPEAT 98..105
FT /note="2"
FT REPEAT 106..113
FT /note="3"
FT REPEAT 114..121
FT /note="4"
FT REPEAT 122..129
FT /note="5"
FT REPEAT 130..137
FT /note="6"
FT REPEAT 138..145
FT /note="7"
FT REPEAT 146..153
FT /note="8"
FT REPEAT 154..161
FT /note="9"
FT REPEAT 162..169
FT /note="10"
FT REPEAT 170..177
FT /note="11"
FT REPEAT 178..185
FT /note="12"
FT REPEAT 186..193
FT /note="13"
FT REPEAT 194..201
FT /note="14"
FT REPEAT 202..209
FT /note="15"
FT REPEAT 210..217
FT /note="16"
FT REPEAT 218..225
FT /note="17"
FT REPEAT 226..233
FT /note="18"
FT REPEAT 234..241
FT /note="19"
FT REPEAT 242..249
FT /note="20"
FT REPEAT 250..257
FT /note="21"
FT REPEAT 258..265
FT /note="22"
FT REPEAT 266..273
FT /note="23"
FT REPEAT 274..281
FT /note="24"
FT REPEAT 282..289
FT /note="25"
FT REPEAT 290..297
FT /note="26"
FT REPEAT 298..305
FT /note="27"
FT REPEAT 306..313
FT /note="28"
FT REPEAT 314..321
FT /note="29"
FT REPEAT 322..329
FT /note="30"
FT REPEAT 330..337
FT /note="31"
FT REPEAT 338..345
FT /note="32"
FT REPEAT 346..353
FT /note="33"
FT REPEAT 354..361
FT /note="34"
FT REPEAT 362..369
FT /note="35"
FT REPEAT 370..377
FT /note="36"
FT REPEAT 378..385
FT /note="37"
FT REPEAT 386..393
FT /note="38"
FT REPEAT 394..401
FT /note="39"
FT REPEAT 402..409
FT /note="40"
FT REPEAT 410..417
FT /note="41"
FT REPEAT 418..425
FT /note="42"
FT REPEAT 426..433
FT /note="43"
FT REPEAT 434..441
FT /note="44"
FT REPEAT 442..449
FT /note="45"
FT REPEAT 450..457
FT /note="46"
FT REPEAT 458..465
FT /note="47"
FT REPEAT 466..473
FT /note="48"
FT REPEAT 474..481
FT /note="49"
FT REPEAT 482..489
FT /note="50"
FT REPEAT 490..497
FT /note="51"
FT REPEAT 498..505
FT /note="52"
FT REPEAT 506..513
FT /note="53"
FT REPEAT 514..521
FT /note="54"
FT REPEAT 522..529
FT /note="55"
FT REPEAT 530..537
FT /note="56"
FT REPEAT 538..545
FT /note="57"
FT REPEAT 546..553
FT /note="58"
FT REPEAT 554..561
FT /note="59"
FT REPEAT 562..569
FT /note="60"
FT REPEAT 570..577
FT /note="61"
FT REPEAT 578..585
FT /note="62"
FT REPEAT 586..593
FT /note="63"
FT REPEAT 594..601
FT /note="64"
FT REPEAT 602..609
FT /note="65"
FT REPEAT 610..617
FT /note="66; approximate"
FT REGION 47..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..617
FT /note="66 X 8 AA approximate tandem repeats of G-P-N-S-D-G-
FT D-K"
FT COMPBIAS 61..76
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 64179 MW; 06FBD18FA144EDB9 CRC64;
MNRILSVSFY LFFLYLYIYK TYGKVKNTDH ELSNIYGIKY YLRNGLSDKK NGKGQKYQDL
EEDENDDEED SNSEESNNDE ENKLIEGQEG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD
KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN
SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD
KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN
SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD
KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN
SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD
KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN
SDGDKGPNSD GDKGPNSDGD KGPNSDGDKG PNSDGDKGPN SDGDKGPNSD GDKGPNSDGD
KGPNSDGDKG PNSDGEHSRS KNDNKKKKSK KNIINMFIGM
