SAP18_ARATH
ID SAP18_ARATH Reviewed; 152 AA.
AC O64644; Q0WTU2; Q8L8K8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Histone deacetylase complex subunit SAP18;
DE AltName: Full=18 kDa Sin3-associated polypeptide;
GN OrderedLocusNames=At2g45640; ORFNames=F17K2.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, INDUCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND
RP INTERACTION WITH ERF3; ERF4 AND HDA19.
RX PubMed=16429262; DOI=10.1007/s11103-005-3880-9;
RA Song C.-P., Galbraith D.W.;
RT "AtSAP18, an orthologue of human SAP18, is involved in the regulation of
RT salt stress and mediates transcriptional repression in Arabidopsis.";
RL Plant Mol. Biol. 60:241-257(2006).
CC -!- FUNCTION: Links the histone deacetylase complex to transcriptional
CC repressors bound to chromatin. Involved in the tethering of the SIN3
CC complex to core histone proteins. {ECO:0000269|PubMed:16429262}.
CC -!- SUBUNIT: Interacts with SIN3, ERF3, ERF4 and HDA19.
CC {ECO:0000269|PubMed:16429262}.
CC -!- INTERACTION:
CC O64644; Q8GWK2: At2g41710; NbExp=3; IntAct=EBI-965964, EBI-25521547;
CC O64644; O80339: ERF3; NbExp=4; IntAct=EBI-965964, EBI-965993;
CC O64644; O80340: ERF4; NbExp=2; IntAct=EBI-965964, EBI-966009;
CC O64644; O22446: HDA19; NbExp=2; IntAct=EBI-965964, EBI-593040;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=O64644-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Ubiquitous, with low level in flowers.
CC {ECO:0000269|PubMed:16429262}.
CC -!- INDUCTION: By salt, cold, drought, abscisic acid and ethylene
CC treatment. {ECO:0000269|PubMed:16429262}.
CC -!- DISRUPTION PHENOTYPE: Plants are hypersensitive to salt.
CC {ECO:0000269|PubMed:16429262}.
CC -!- SIMILARITY: Belongs to the SAP18 family. {ECO:0000305}.
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DR EMBL; AC003680; AAC06174.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10580.1; -; Genomic_DNA.
DR EMBL; AF378876; AAK55679.1; -; mRNA.
DR EMBL; AY050474; AAK91487.1; -; mRNA.
DR EMBL; AY088934; AAM67239.1; -; mRNA.
DR EMBL; AK227453; BAE99456.1; -; mRNA.
DR PIR; T00877; T00877.
DR RefSeq; NP_566050.1; NM_130126.4. [O64644-1]
DR AlphaFoldDB; O64644; -.
DR SMR; O64644; -.
DR BioGRID; 4508; 19.
DR IntAct; O64644; 6.
DR STRING; 3702.AT2G45640.1; -.
DR MetOSite; O64644; -.
DR PaxDb; O64644; -.
DR PRIDE; O64644; -.
DR ProteomicsDB; 226664; -. [O64644-1]
DR EnsemblPlants; AT2G45640.1; AT2G45640.1; AT2G45640. [O64644-1]
DR GeneID; 819172; -.
DR Gramene; AT2G45640.1; AT2G45640.1; AT2G45640. [O64644-1]
DR KEGG; ath:AT2G45640; -.
DR Araport; AT2G45640; -.
DR TAIR; locus:2043704; AT2G45640.
DR eggNOG; KOG3391; Eukaryota.
DR InParanoid; O64644; -.
DR OMA; VYPNFRN; -.
DR PhylomeDB; O64644; -.
DR PRO; PR:O64644; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O64644; baseline and differential.
DR Genevisible; O64644; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR Gene3D; 3.10.20.550; -; 1.
DR InterPro; IPR017250; Hist_deAcase_cplx_SAP18.
DR InterPro; IPR010516; SAP18.
DR InterPro; IPR042534; SAP18_sf.
DR PANTHER; PTHR13082; PTHR13082; 1.
DR Pfam; PF06487; SAP18; 1.
DR PIRSF; PIRSF037637; HDAC_SAP18; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repressor; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..152
FT /note="Histone deacetylase complex subunit SAP18"
FT /id="PRO_0000220979"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 62
FT /note="G -> S (in Ref. 4; AAM67239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 152 AA; 17164 MW; 0F2ECE3C77234B6B CRC64;
MAEAARRQGG GRPLPPPPRG VNQQPPRPKP EPVDREKTCP LLLRVFTKSG GHHTSEDYAV
RGKEPKDEVQ IYTWKDASLR ELTDLVKEVS VAARRRNARL SFAFVYPNNK GGYNVREVGE
TMAYPNRKQP DDSKTLSELP FEIGDYLDVA IY
