ID   SAP18_CAEEL             Reviewed;         166 AA.
AC   Q09250;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Probable histone deacetylase complex subunit SAP18;
DE   AltName: Full=18 kDa Sin3-associated polypeptide;
GN   ORFNames=C16C10.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Acts in transcription repression. Involved in the tethering
CC       of the SIN3 complex to core histone proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SIN3 and histone deacetylase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAP18 family. {ECO:0000305}.
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DR   EMBL; Z46787; CAA86742.1; -; Genomic_DNA.
DR   PIR; T19325; T19325.
DR   RefSeq; NP_497833.1; NM_065432.4.
DR   AlphaFoldDB; Q09250; -.
DR   SMR; Q09250; -.
DR   BioGRID; 40771; 6.
DR   IntAct; Q09250; 1.
DR   STRING; 6239.C16C10.4.3; -.
DR   iPTMnet; Q09250; -.
DR   EPD; Q09250; -.
DR   PaxDb; Q09250; -.
DR   PeptideAtlas; Q09250; -.
DR   EnsemblMetazoa; C16C10.4.1; C16C10.4.1; WBGene00007625.
DR   EnsemblMetazoa; C16C10.4.2; C16C10.4.2; WBGene00007625.
DR   GeneID; 175534; -.
DR   KEGG; cel:CELE_C16C10.4; -.
DR   UCSC; C16C10.4.2; c. elegans.
DR   CTD; 175534; -.
DR   WormBase; C16C10.4; CE01495; WBGene00007625; -.
DR   eggNOG; KOG3391; Eukaryota.
DR   GeneTree; ENSGT00390000003152; -.
DR   HOGENOM; CLU_108681_0_1_1; -.
DR   InParanoid; Q09250; -.
DR   OMA; VYPNFRN; -.
DR   OrthoDB; 1622057at2759; -.
DR   PhylomeDB; Q09250; -.
DR   PRO; PR:Q09250; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007625; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 3.10.20.550; -; 1.
DR   InterPro; IPR010516; SAP18.
DR   InterPro; IPR042534; SAP18_sf.
DR   PANTHER; PTHR13082; PTHR13082; 1.
DR   Pfam; PF06487; SAP18; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..166
FT                   /note="Probable histone deacetylase complex subunit SAP18"
FT                   /id="PRO_0000220977"
FT   REGION          143..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   166 AA;  18971 MW;  9FC5E4B90E4E0FF9 CRC64;
     MSNGQLVSQV TVGHDKPLDR EKVCPMLLRV FVANNRHNPM SEYNSRNGGS VPPSELQMHT
     WMDCSLRELT SLIKEVNPDA RRKGTTFDFA IVQADRGSPR YILRDVGNTT NGERGIDDNK
     TLQQCKFEVG DFVDVAISLP SQGRRFNNRE QGDRFDHRQR QRSPIR