SAP25_HUMAN
ID SAP25_HUMAN Reviewed; 199 AA.
AC Q8TEE9;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Histone deacetylase complex subunit SAP25;
DE AltName: Full=25 kDa Sin3-associated polypeptide;
DE AltName: Full=Sin3 corepressor complex subunit SAP25;
GN Name=SAP25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Leukocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH SIN3A.
RX PubMed=16449650; DOI=10.1128/mcb.26.4.1386-1397.2006;
RA Shiio Y., Rose D.W., Aur R., Donohoe S., Aebersold R., Eisenman R.N.;
RT "Identification and characterization of SAP25, a novel component of the
RT mSin3 corepressor complex.";
RL Mol. Cell. Biol. 26:1386-1397(2006).
CC -!- FUNCTION: Involved in the transcriptional repression mediated by the
CC mSIN3A but not the N-CoR corepressor complex. {ECO:0000250}.
CC -!- SUBUNIT: May be a component of the mSIN3A corepressor complex.
CC Interacts with SIN3A. Interacts with HDAC2 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85001.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AK074175; BAB85001.1; ALT_SEQ; mRNA.
DR EMBL; BC046135; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS55137.1; -.
DR RefSeq; NP_001335606.1; NM_001348677.1.
DR AlphaFoldDB; Q8TEE9; -.
DR BioGRID; 941018; 28.
DR CORUM; Q8TEE9; -.
DR IntAct; Q8TEE9; 4.
DR MINT; Q8TEE9; -.
DR STRING; 9606.ENSP00000481351; -.
DR iPTMnet; Q8TEE9; -.
DR PhosphoSitePlus; Q8TEE9; -.
DR BioMuta; SAP25; -.
DR DMDM; 206558307; -.
DR MassIVE; Q8TEE9; -.
DR PaxDb; Q8TEE9; -.
DR PeptideAtlas; Q8TEE9; -.
DR PRIDE; Q8TEE9; -.
DR Antibodypedia; 71354; 5 antibodies from 5 providers.
DR DNASU; 100316904; -.
DR Ensembl; ENST00000538735.5; ENSP00000442339.1; ENSG00000205307.12.
DR Ensembl; ENST00000614631.4; ENSP00000481351.1; ENSG00000205307.12.
DR GeneID; 100316904; -.
DR KEGG; hsa:100316904; -.
DR UCSC; uc022aip.2; human.
DR CTD; 100316904; -.
DR GeneCards; SAP25; -.
DR HGNC; HGNC:41908; SAP25.
DR HPA; ENSG00000205307; Tissue enhanced (lymphoid).
DR MIM; 619230; gene.
DR neXtProt; NX_Q8TEE9; -.
DR OpenTargets; ENSG00000205307; -.
DR VEuPathDB; HostDB:ENSG00000205307; -.
DR eggNOG; ENOG502SWKH; Eukaryota.
DR GeneTree; ENSGT00390000007899; -.
DR HOGENOM; CLU_085239_0_0_1; -.
DR InParanoid; Q8TEE9; -.
DR OMA; AGPQPVW; -.
DR PhylomeDB; Q8TEE9; -.
DR TreeFam; TF350622; -.
DR PathwayCommons; Q8TEE9; -.
DR SignaLink; Q8TEE9; -.
DR BioGRID-ORCS; 100316904; 13 hits in 1020 CRISPR screens.
DR Pharos; Q8TEE9; Tdark.
DR PRO; PR:Q8TEE9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8TEE9; protein.
DR Bgee; ENSG00000205307; Expressed in granulocyte and 92 other tissues.
DR ExpressionAtlas; Q8TEE9; baseline and differential.
DR Genevisible; Q8TEE9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR029163; SAP25.
DR PANTHER; PTHR39231; PTHR39231; 1.
DR Pfam; PF15476; SAP25; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..199
FT /note="Histone deacetylase complex subunit SAP25"
FT /id="PRO_0000350873"
FT REGION 151..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 199 AA; 20873 MW; F0ADC8A992B40BE2 CRC64;
MTPLAPWDPK YEAKAGPRPV WGANCSSGAS FSGRTLCHPS FWPLYEAASG RGLRPVAPAT
GHWNGQQAPP DAGFPVVCCE DVFLSDPLLP RGQRVPLYLS KAPQQMMGSL KLLPPPPIMS
ARVLPRPSPS RGPSTAWLSG PELIALTGLL QMSQGEPRPS SSAVGPPDHT SDPPSPCGSP
SSSQGADLSL PQTPDTHCP
