SAP2_ARBPU
ID SAP2_ARBPU Reviewed; 14 AA.
AC P11760;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Resact;
DE AltName: Full=SAP-IIA;
DE AltName: Full=Sperm-activating peptide;
OS Arbacia punctulata (Punctuate sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Arbacioida; Arbaciidae; Arbacia.
OX NCBI_TaxID=7641;
RN [1]
RP PROTEIN SEQUENCE, AND AMIDATION AT LEU-14.
RC TISSUE=Egg;
RX PubMed=6150045; DOI=10.1016/s0021-9258(17)42685-8;
RA Suzuki N., Shimomura H., Radany E.W., Ramarao C.S., Ward G.E.,
RA Bentley J.K., Garbers D.L.;
RT "A peptide associated with eggs causes a mobility shift in a major plasma
RT membrane protein of spermatozoa.";
RL J. Biol. Chem. 259:14874-14879(1984).
RN [2]
RP DISULFIDE BOND.
RX PubMed=1756858; DOI=10.1016/0014-5793(91)80663-n;
RA Yoshino K., Takao T., Shimonishi Y., Suzuki N.;
RT "Determination of the amino acid sequence of an intramolecular disulfide
RT linkage-containing sperm-activating peptide by tandem mass spectrometry.";
RL FEBS Lett. 294:179-182(1991).
CC -!- FUNCTION: Causes stimulation of sperm respiration and motility through
CC intracellular alkalinization, transient elevations of cAMP, cGMP and
CC calcium levels in sperm cells, and transient activation and subsequent
CC inactivation of the membrane form of guanylate cyclase.
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PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond.
FT PEPTIDE 1..14
FT /note="Resact"
FT /id="PRO_0000044215"
FT MOD_RES 14
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:6150045"
FT DISULFID 1..8
FT /evidence="ECO:0000269|PubMed:1756858"
SQ SEQUENCE 14 AA; 1246 MW; 39745AA33EBE41B8 CRC64;
CVTGAPGCVG GGRL