ID   SAP30_AEDAE             Reviewed;         173 AA.
AC   Q17Q39;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Histone deacetylase complex subunit SAP30 homolog;
GN   ORFNames=AAEL000149;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Required for the function of the class 1 Sin3-histone
CC       deacetylase complex (HDAC). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the class 1 Sin3-histone deacetylase complex
CC       (HDAC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAP30 family. {ECO:0000305}.
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DR   EMBL; CH477187; EAT48877.1; -; Genomic_DNA.
DR   RefSeq; XP_001657686.1; XM_001657636.1.
DR   AlphaFoldDB; Q17Q39; -.
DR   SMR; Q17Q39; -.
DR   STRING; 7159.AAEL000149-PA; -.
DR   GeneID; 5567784; -.
DR   KEGG; aag:5567784; -.
DR   VEuPathDB; VectorBase:AAEL000149; -.
DR   eggNOG; ENOG502QWFH; Eukaryota.
DR   HOGENOM; CLU_097961_1_0_1; -.
DR   InParanoid; Q17Q39; -.
DR   OMA; QCARTKR; -.
DR   OrthoDB; 1520155at2759; -.
DR   PhylomeDB; Q17Q39; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.160.20; -; 1.
DR   InterPro; IPR024145; His_deAcase_SAP30/SAP30L.
DR   InterPro; IPR038291; SAP30_C_sf.
DR   InterPro; IPR025718; SAP30_Sin3-bd.
DR   InterPro; IPR025717; SAP30_zn-finger.
DR   PANTHER; PTHR13286; PTHR13286; 1.
DR   Pfam; PF13867; SAP30_Sin3_bdg; 1.
DR   Pfam; PF13866; zf-SAP30; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..173
FT                   /note="Histone deacetylase complex subunit SAP30 homolog"
FT                   /id="PRO_0000309506"
FT   ZN_FING         21..69
FT                   /note="Atypical"
SQ   SEQUENCE   173 AA;  20106 MW;  717307997644FB02 CRC64;
     MNNNGFSTGE EDSRGPADQV CCLLDDGDRC RNQAGNASYS KRIQKTVTQR RLKLSIDTAA
     RHIYICDFHK GRIQCARTKR RRRDSEDDSN ETDTDLPEVD LYQLQVNTLR RYKRFYKVST
     RPGINKAQLS ETIMKHFKTI PIKEKEILTY FIYMVKSNSN KLDQKNNTSN EAT