ID   SAP30_ANOGA             Reviewed;         174 AA.
AC   Q7PXY4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 4.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Histone deacetylase complex subunit SAP30 homolog;
GN   ORFNames=AGAP001654;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Required for the function of the class 1 Sin3-histone
CC       deacetylase complex (HDAC). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the class 1 Sin3-histone deacetylase complex
CC       (HDAC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAP30 family. {ECO:0000305}.
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DR   EMBL; AAAB01008987; EAA00919.4; -; Genomic_DNA.
DR   RefSeq; XP_321441.4; XM_321441.4.
DR   AlphaFoldDB; Q7PXY4; -.
DR   SMR; Q7PXY4; -.
DR   STRING; 7165.AGAP001654-PA; -.
DR   PaxDb; Q7PXY4; -.
DR   GeneID; 1281519; -.
DR   KEGG; aga:AgaP_AGAP001654; -.
DR   CTD; 1281519; -.
DR   VEuPathDB; VectorBase:AGAP001654; -.
DR   eggNOG; ENOG502QWFH; Eukaryota.
DR   HOGENOM; CLU_097961_1_0_1; -.
DR   InParanoid; Q7PXY4; -.
DR   OMA; QCARTKR; -.
DR   OrthoDB; 1520155at2759; -.
DR   PhylomeDB; Q7PXY4; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 6.10.160.20; -; 1.
DR   InterPro; IPR024145; His_deAcase_SAP30/SAP30L.
DR   InterPro; IPR038291; SAP30_C_sf.
DR   InterPro; IPR025718; SAP30_Sin3-bd.
DR   InterPro; IPR025717; SAP30_zn-finger.
DR   PANTHER; PTHR13286; PTHR13286; 1.
DR   Pfam; PF13867; SAP30_Sin3_bdg; 1.
DR   Pfam; PF13866; zf-SAP30; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..174
FT                   /note="Histone deacetylase complex subunit SAP30 homolog"
FT                   /id="PRO_0000309507"
FT   ZN_FING         22..70
FT                   /note="Atypical"
SQ   SEQUENCE   174 AA;  20276 MW;  6DDEE25C55D899B6 CRC64;
     MMNNNGFSTG EEDSRGPADQ ICCLLDDGER CRKQAGNASY SKRIQKTVTQ RRLKLSIDSH
     ARHIYICDFH KARIQCARTK RRRRDSEDDS NETDTDLPEV DLYQLQVNTL RRYKRFYKVS
     TRPSSNKAQL SETIMKHFKT IPIKEKEILT YFIYMVKSNS NKLDQKNNAS AEAT