SAP30_DROPS
ID SAP30_DROPS Reviewed; 173 AA.
AC Q29IK8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Histone deacetylase complex subunit SAP30 homolog;
GN Name=Sap30; ORFNames=GA18408;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Component of the class 1 Sin3A-histone deacetylase
CC (HDAC1/Rpd3) complex (HDAC). Appears to be a non-essential subunit of
CC this complex which is not required for cell cycle regulation of
CC progression through the G2 phase of the cell cycle (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the class 1 Sin3A-histone deacetylase
CC (HDAC1/Rpd3) complex (HDAC). Not essential for stability of the
CC complex, recruitment of the complex to some promoters, or the
CC deacetylase activity of the complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SAP30 family. {ECO:0000305}.
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DR EMBL; CH379063; EAL32645.1; -; Genomic_DNA.
DR RefSeq; XP_001355586.1; XM_001355550.2.
DR RefSeq; XP_015041275.1; XM_015185789.1.
DR AlphaFoldDB; Q29IK8; -.
DR SMR; Q29IK8; -.
DR STRING; 7237.FBpp0273538; -.
DR PRIDE; Q29IK8; -.
DR EnsemblMetazoa; FBtr0275100; FBpp0273538; FBgn0078410.
DR EnsemblMetazoa; FBtr0366910; FBpp0329975; FBgn0078410.
DR GeneID; 4815625; -.
DR KEGG; dpo:Dpse_GA18408; -.
DR eggNOG; ENOG502QWFH; Eukaryota.
DR HOGENOM; CLU_097961_1_0_1; -.
DR InParanoid; Q29IK8; -.
DR OMA; QCARTKR; -.
DR PhylomeDB; Q29IK8; -.
DR ChiTaRS; Sap30; fly.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0078410; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0000118; C:histone deacetylase complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR Gene3D; 6.10.160.20; -; 1.
DR InterPro; IPR024145; His_deAcase_SAP30/SAP30L.
DR InterPro; IPR038291; SAP30_C_sf.
DR InterPro; IPR025718; SAP30_Sin3-bd.
DR InterPro; IPR025717; SAP30_zn-finger.
DR PANTHER; PTHR13286; PTHR13286; 1.
DR Pfam; PF13867; SAP30_Sin3_bdg; 1.
DR Pfam; PF13866; zf-SAP30; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..173
FT /note="Histone deacetylase complex subunit SAP30 homolog"
FT /id="PRO_0000309509"
FT ZN_FING 20..68
FT /note="Atypical"
FT REGION 73..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 91
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
FT MOD_RES 93
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 173 AA; 20250 MW; B48F67DC8CCCB441 CRC64;
MNNGFSTGEE DSRGHADQTC CLIDDMERCR NQAGYASYSK RIQKTVAQKR LRLSSDPSAQ
HIYICDHHKE RIQSVRTKRR RKDSEDDSNE TDTDLHEFPD LYQLSVSTLR RYKRHFKVQT
RQGMKRAQLA DTIMKHFKTI PIKEKEIITF FVYMVKMGTN KLDQKNGIGN DTT
