ID   SAP49_SCHPO             Reviewed;         335 AA.
AC   O14102; Q9HDX0;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Spliceosome-associated protein 49;
GN   Name=sap49; ORFNames=SPAC31G5.01, SPAPB1A11.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SF3B4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAC19730.1; -; Genomic_DNA.
DR   RefSeq; NP_594001.2; NM_001019427.2.
DR   AlphaFoldDB; O14102; -.
DR   SMR; O14102; -.
DR   BioGRID; 278888; 13.
DR   IntAct; O14102; 4.
DR   STRING; 4896.SPAC31G5.01.1; -.
DR   MaxQB; O14102; -.
DR   PaxDb; O14102; -.
DR   EnsemblFungi; SPAC31G5.01.1; SPAC31G5.01.1:pep; SPAC31G5.01.
DR   GeneID; 2542426; -.
DR   KEGG; spo:SPAC31G5.01; -.
DR   PomBase; SPAC31G5.01; sap49.
DR   VEuPathDB; FungiDB:SPAC31G5.01; -.
DR   eggNOG; KOG0131; Eukaryota.
DR   HOGENOM; CLU_012062_21_2_1; -.
DR   InParanoid; O14102; -.
DR   OMA; HWEQNKE; -.
DR   PhylomeDB; O14102; -.
DR   PRO; PR:O14102; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005686; C:U2 snRNP; IDA:PomBase.
DR   GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR   GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; TAS:PomBase.
DR   CDD; cd12334; RRM1_SF3B4; 1.
DR   CDD; cd12335; RRM2_SF3B4; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034158; SF3B4_RRM1.
DR   InterPro; IPR034159; SF3B4_RRM2.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..335
FT                   /note="Spliceosome-associated protein 49"
FT                   /id="PRO_0000081957"
FT   DOMAIN          13..84
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          101..172
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          204..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  35908 MW;  5F05F7CDF7144400 CRC64;
     MSIREDRNQD ATIYLGNLDE KVTDSILFEL CLQAGPVVNI HIPRDRVRNS HNGFGFCEFL
     HEQDVEYACQ ILNQVKLFGK PIRVNRASQD RGVNTLIGAN LFVGNLDPLV DERVLYDTFS
     ALGQLVKAPQ VARDENGRSK GYGFVSYDSF ETADAAIEAM NNQFLMNKPI TVSYAFKREG
     KGERHGDIAE RKLAAAAKKN KVAVTPQSTL PPGFSPATPA PTSAANTPAT IAATSIPPVP
     NVPLVGATTA VPPLSIPNVL PFTAAQHFPG MPAMPMMNVP MGPGGAPLVP PPPPGMVMAS
     PSPAAATIPG APVMPNIPFY QTINAQNGYS QQQRR