SAPC1_HUMAN
ID SAPC1_HUMAN Reviewed; 148 AA.
AC Q5SSQ6; A2ABF2; A2ABS9; Q9Y335;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Suppressor APC domain-containing protein 1;
DE AltName: Full=Protein G7d;
GN Name=SAPCD1; Synonyms=C6orf26, G7D, NG23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5SSQ6-2; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-13072754, EBI-11524452;
CC Q5SSQ6-2; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-13072754, EBI-743105;
CC Q5SSQ6-2; O14964: HGS; NbExp=3; IntAct=EBI-13072754, EBI-740220;
CC Q5SSQ6-2; O75031: HSF2BP; NbExp=3; IntAct=EBI-13072754, EBI-7116203;
CC Q5SSQ6-2; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-13072754, EBI-10226430;
CC Q5SSQ6-2; O15273: TCAP; NbExp=3; IntAct=EBI-13072754, EBI-954089;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SSQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SSQ6-2; Sequence=VSP_040223;
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DR EMBL; AF134726; AAD21821.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63305.1; -; Genomic_DNA.
DR EMBL; AL662834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR925765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137541; AAI37542.1; -; mRNA.
DR EMBL; BC137542; AAI37543.1; -; mRNA.
DR CCDS; CCDS34411.1; -. [Q5SSQ6-2]
DR RefSeq; NP_001034740.1; NM_001039651.1. [Q5SSQ6-2]
DR AlphaFoldDB; Q5SSQ6; -.
DR SMR; Q5SSQ6; -.
DR BioGRID; 134996; 22.
DR IntAct; Q5SSQ6; 12.
DR iPTMnet; Q5SSQ6; -.
DR PhosphoSitePlus; Q5SSQ6; -.
DR BioMuta; SAPCD1; -.
DR DMDM; 109829408; -.
DR MassIVE; Q5SSQ6; -.
DR PeptideAtlas; Q5SSQ6; -.
DR PRIDE; Q5SSQ6; -.
DR ProteomicsDB; 63885; -. [Q5SSQ6-1]
DR ProteomicsDB; 63886; -. [Q5SSQ6-2]
DR Antibodypedia; 70925; 23 antibodies from 9 providers.
DR DNASU; 401251; -.
DR Ensembl; ENST00000415669.3; ENSP00000411948.2; ENSG00000228727.9. [Q5SSQ6-2]
DR Ensembl; ENST00000425424.4; ENSP00000413372.1; ENSG00000228727.9. [Q5SSQ6-1]
DR Ensembl; ENST00000443153.5; ENSP00000403687.2; ENSG00000227074.11. [Q5SSQ6-2]
DR Ensembl; ENST00000447852.3; ENSP00000403346.2; ENSG00000227861.9. [Q5SSQ6-2]
DR Ensembl; ENST00000449857.3; ENSP00000387942.2; ENSG00000237918.9. [Q5SSQ6-2]
DR Ensembl; ENST00000453534.5; ENSP00000404105.2; ENSG00000234951.9. [Q5SSQ6-2]
DR Ensembl; ENST00000457185.4; ENSP00000405513.2; ENSG00000229176.11. [Q5SSQ6-2]
DR Ensembl; ENST00000547662.3; ENSP00000447344.1; ENSG00000229176.11. [Q5SSQ6-1]
DR Ensembl; ENST00000548987.3; ENSP00000448208.1; ENSG00000227074.11. [Q5SSQ6-1]
DR Ensembl; ENST00000551778.3; ENSP00000450257.1; ENSG00000234951.9. [Q5SSQ6-1]
DR GeneID; 401251; -.
DR KEGG; hsa:401251; -.
DR MANE-Select; ENST00000415669.4; ENSP00000411948.2; NM_001039651.2; NP_001034740.1. [Q5SSQ6-2]
DR UCSC; uc063nhd.1; human. [Q5SSQ6-1]
DR CTD; 401251; -.
DR DisGeNET; 401251; -.
DR GeneCards; SAPCD1; -.
DR HGNC; HGNC:13938; SAPCD1.
DR HPA; ENSG00000228727; Tissue enhanced (skin).
DR neXtProt; NX_Q5SSQ6; -.
DR OpenTargets; ENSG00000228727; -.
DR PharmGKB; PA134974558; -.
DR VEuPathDB; HostDB:ENSG00000228727; -.
DR GeneTree; ENSGT00500000045192; -.
DR InParanoid; Q5SSQ6; -.
DR OMA; RQDALWQ; -.
DR PhylomeDB; Q5SSQ6; -.
DR TreeFam; TF324086; -.
DR PathwayCommons; Q5SSQ6; -.
DR SignaLink; Q5SSQ6; -.
DR BioGRID-ORCS; 401251; 13 hits in 1068 CRISPR screens.
DR GenomeRNAi; 401251; -.
DR Pharos; Q5SSQ6; Tdark.
DR PRO; PR:Q5SSQ6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5SSQ6; protein.
DR Bgee; ENSG00000228727; Expressed in skin of leg and 91 other tissues.
DR ExpressionAtlas; Q5SSQ6; baseline and differential.
DR Genevisible; Q5SSQ6; HS.
DR InterPro; IPR026828; Suppressor_APCD_1/2.
DR PANTHER; PTHR14907; PTHR14907; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..148
FT /note="Suppressor APC domain-containing protein 1"
FT /id="PRO_0000244082"
FT REGION 120..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 117
FT /note="K -> KFSPSPLNKASSCTTQDSKERRREQNLWQQQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040223"
FT VARIANT 30
FT /note="P -> S (in dbSNP:rs17201151)"
FT /id="VAR_056889"
FT VARIANT 99
FT /note="P -> L (in dbSNP:rs6905572)"
FT /id="VAR_056890"
SQ SEQUENCE 148 AA; 16650 MW; 6311AF525675DDFF CRC64;
MGSQGSGGVP LVQAPYTVLL LPLGTSRQDP GAQSFFLWLR RMQALEREQD ALWQGLELLQ
HGQAWFEDHL REAQRQQLHL GALGENFLTD LHSEPGRPPL AQIQKVNICL QNLIHEKELS
RQQKGVTQPK EEMAQRGCTK GPRGPTRV
