ID   SAPD_SHIFL              Reviewed;         330 AA.
AC   P0AAH7; P36635;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Peptide transport system ATP-binding protein SapD;
GN   Name=sapD; OrderedLocusNames=SF1296, S1378;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Involved in a peptide intake transport system that plays a
CC       role in the resistance to antimicrobial peptides. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005674; AAN42907.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16790.1; -; Genomic_DNA.
DR   RefSeq; NP_707200.1; NC_004337.2.
DR   RefSeq; WP_001128858.1; NZ_WPGW01000009.1.
DR   AlphaFoldDB; P0AAH7; -.
DR   SMR; P0AAH7; -.
DR   STRING; 198214.SF1296; -.
DR   EnsemblBacteria; AAN42907; AAN42907; SF1296.
DR   EnsemblBacteria; AAP16790; AAP16790; S1378.
DR   GeneID; 1024262; -.
DR   GeneID; 67417384; -.
DR   KEGG; sfl:SF1296; -.
DR   KEGG; sfx:S1378; -.
DR   PATRIC; fig|198214.7.peg.1522; -.
DR   HOGENOM; CLU_000604_1_23_6; -.
DR   OMA; PHGRVKA; -.
DR   OrthoDB; 1101128at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR013563; Oligopep_ABC_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08352; oligo_HPY; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01727; oligo_HPY; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Peptide transport; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..330
FT                   /note="Peptide transport system ATP-binding protein SapD"
FT                   /id="PRO_0000092966"
FT   DOMAIN          6..259
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   330 AA;  37661 MW;  1326280E475628E0 CRC64;
     MPLLDIRNLT IEFKTGDEWV KAVDRVSMTL TEGEIRGLVG ESGSGKSLIA KAICGVNKDN
     WRVTADRMRF DDIDLLRLSA RERRKLVGHN VSMIFQEPQS CLDPSERVGR QLMQNIPAWT
     YKGRWWQRFG WRKRRAIELL HRVGIKDHKD AMRSFPYELT EGECQKVMIA IALANQPRLL
     IADEPTNSME PTTQAQIFRL LTRLNQNSNT TILLISHDLQ MLSQWADKIN VLYCGQTVET
     APSKELVTMP HHPYTQALIR AIPDFGSAMP HKSRLNTLPG AIPLLEQLPI GCRLGPRCPY
     AQRECIVTPR LTGAKNHLYA CHFPLNMEKE