SAPF_HAEIN
ID SAPF_HAEIN Reviewed; 269 AA.
AC P45289;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Peptide transport system ATP-binding protein SapF;
GN Name=sapF; OrderedLocusNames=HI_1642;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Involved in a peptide intake transport system that plays a
CC role in the resistance to antimicrobial peptides. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; L42023; AAC23289.1; -; Genomic_DNA.
DR PIR; E64134; E64134.
DR RefSeq; NP_439784.1; NC_000907.1.
DR RefSeq; WP_005670537.1; NC_000907.1.
DR AlphaFoldDB; P45289; -.
DR SMR; P45289; -.
DR STRING; 71421.HI_1642; -.
DR EnsemblBacteria; AAC23289; AAC23289; HI_1642.
DR KEGG; hin:HI_1642; -.
DR PATRIC; fig|71421.8.peg.1718; -.
DR eggNOG; COG4172; Bacteria.
DR HOGENOM; CLU_000604_1_23_6; -.
DR OMA; PEIDRKW; -.
DR PhylomeDB; P45289; -.
DR BioCyc; HINF71421:G1GJ1-1659-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Peptide transport; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..269
FT /note="Peptide transport system ATP-binding protein SapF"
FT /id="PRO_0000092972"
FT DOMAIN 4..249
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 45..52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 269 AA; 30295 MW; E5C044EECBDE801F CRC64;
MPLLQVEDLT KTFKGHASLF GRNQFNAVDK VSFTLERKQT LAIIGNNGSG KSTLVKMIAG
IIPPTSGRIL FNDRELQYQD AQSRAKHIRM VFQDANSAFN PRLNIGQILD EPLSLATDWT
ETQRNEKIFE TLSLVGLYPD YTNLNIKHLS ISQKQRVALA RALILEPEII IIDDAIGNLD
ASVRIQLLNL TLDLQQRLGI SYIYVGQDLG VIKHIADTII VMDEGKMIEY GSPQNLFTDP
QTDVTRRLVE SYFGKILDET AWVKDKNAH
