ID   SAPF_SALTY              Reviewed;         268 AA.
AC   P36638;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Peptide transport system ATP-binding protein SapF;
GN   Name=sapF {ECO:0000303|PubMed:8223423}; OrderedLocusNames=STM1696;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, OPERON STRUCTURE, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=8223423; DOI=10.1002/j.1460-2075.1993.tb06089.x;
RA   Parra-Lopez C., Baer M.T., Groisman E.A.;
RT   "Molecular genetic analysis of a locus required for resistance to
RT   antimicrobial peptides in Salmonella typhimurium.";
RL   EMBO J. 12:4053-4062(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in a peptide intake transport system that plays a
CC       role in the resistance to antimicrobial peptides.
CC       {ECO:0000269|PubMed:8223423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Part of the sapA-sapB-sapC-sapD-sapF operon, RNA detected in
CC       mid-log phase cells. {ECO:0000269|PubMed:8223423}.
CC   -!- DISRUPTION PHENOTYPE: Loss of resistance to protamine.
CC       {ECO:0000269|PubMed:8223423}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; X74212; CAA52288.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20613.1; -; Genomic_DNA.
DR   PIR; S39589; S39589.
DR   RefSeq; NP_460654.1; NC_003197.2.
DR   RefSeq; WP_000230462.1; NC_003197.2.
DR   AlphaFoldDB; P36638; -.
DR   SMR; P36638; -.
DR   STRING; 99287.STM1696; -.
DR   TCDB; 3.A.1.5.5; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P36638; -.
DR   EnsemblBacteria; AAL20613; AAL20613; STM1696.
DR   GeneID; 1253214; -.
DR   KEGG; stm:STM1696; -.
DR   PATRIC; fig|99287.12.peg.1790; -.
DR   HOGENOM; CLU_000604_1_23_6; -.
DR   OMA; PEIDRKW; -.
DR   PhylomeDB; P36638; -.
DR   BioCyc; SENT99287:STM1696-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Peptide transport; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..268
FT                   /note="Peptide transport system ATP-binding protein SapF"
FT                   /id="PRO_0000092970"
FT   DOMAIN          6..251
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         47..54
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   268 AA;  30672 MW;  339B649A75252504 CRC64;
     MVETLLEVRN LSKTFRYRTG WFRRQTVDAV KPLSFTLRER QTLAIIGENG SGKSTLAKML
     AGMIEPTSGE LLIDDHPLHY GDYSFRSQRI RMIFQDPSTS LNPRQRISQI LDFPLRLNTD
     LEPEQRRKQI VETMRMVGLL PDHVSYYPHM LAPGQKQRLG LARALILRPK VIIADEALAS
     LDMSMRSQLI NLMLELQEKQ GISYIYVTQH IGMMKHISDQ VLVMHQGEVV ERGSTADVLA
     SPLHELTRRL IAGHFGEALT ADAWRKDR