ID   SAPR_STRPU              Reviewed;         296 AA.
AC   P11761;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Sperm-activating peptides;
DE   Contains:
DE     RecName: Full=Speract;
DE   Contains:
DE     RecName: Full=Speract-like 1;
DE   Contains:
DE     RecName: Full=Speract-like 2;
DE   Contains:
DE     RecName: Full=Speract-like 3;
DE   Contains:
DE     RecName: Full=Speract-like 4;
DE   Contains:
DE     RecName: Full=Speract-like 5;
DE   Flags: Precursor;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=2334699; DOI=10.1021/bi00465a034;
RA   Ramarao C.S., Burks D.J., Garbers D.L.;
RT   "A single mRNA encodes multiple copies of the egg peptide speract.";
RL   Biochemistry 29:3383-3388(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF SPERACT, AND SYNTHESIS.
RC   TISSUE=Egg;
RX   PubMed=7061446; DOI=10.1016/s0021-9258(19)81020-7;
RA   Garbers D.L., Watkins H.D., Hansbrough J.R., Smith A., Misono K.S.;
RT   "The amino acid sequence and chemical synthesis of speract and of speract
RT   analogues.";
RL   J. Biol. Chem. 257:2734-2737(1982).
RN   [3]
RP   PROTEIN SEQUENCE OF SPERACT.
RC   TISSUE=Egg;
RX   PubMed=6256397; DOI=10.1016/s0021-9258(19)69983-7;
RA   Hansbrough J.R., Garbers D.L.;
RT   "Speract. Purification and characterization of a peptide associated with
RT   eggs that activates spermatozoa.";
RL   J. Biol. Chem. 256:1447-1452(1981).
CC   -!- FUNCTION: Causes stimulation of sperm respiration and motility through
CC       intracellular alkalinization, transient elevations of cAMP, cGMP and
CC       calcium levels in sperm cells, and transient activation and subsequent
CC       inactivation of the membrane form of guanylate cyclase.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA30080.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; J02896; AAA30079.1; -; mRNA.
DR   EMBL; J02896; AAA30080.1; ALT_INIT; mRNA.
DR   PIR; A34543; A34543.
DR   RefSeq; NP_999771.1; NM_214606.1.
DR   AlphaFoldDB; P11761; -.
DR   EnsemblMetazoa; NM_214606.1-2; NP_999771; LOC373457-2.
DR   GeneID; 373457; -.
DR   KEGG; spu:373457; -.
DR   OMA; SEDYMET; -.
DR   PhylomeDB; P11761; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Reference proteome.
FT   PROPEP          1..134
FT                   /id="PRO_0000278269"
FT   PEPTIDE         135..144
FT                   /note="Speract-like 5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022271"
FT   PROPEP          146..190
FT                   /id="PRO_0000278270"
FT   PEPTIDE         191..200
FT                   /note="Speract-like 4"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022272"
FT   PEPTIDE         202..211
FT                   /note="Speract-like 1"
FT                   /id="PRO_0000022273"
FT   PEPTIDE         213..222
FT                   /note="Speract-like 2"
FT                   /id="PRO_0000022274"
FT   PEPTIDE         224..233
FT                   /note="Speract"
FT                   /id="PRO_0000022275"
FT   PEPTIDE         235..244
FT                   /note="Speract"
FT                   /id="PRO_0000022276"
FT   PEPTIDE         246..255
FT                   /note="Speract"
FT                   /id="PRO_0000022277"
FT   PEPTIDE         257..266
FT                   /note="Speract"
FT                   /id="PRO_0000022278"
FT   PEPTIDE         268..277
FT                   /note="Speract-like 1"
FT                   /id="PRO_0000022279"
FT   PEPTIDE         279..288
FT                   /note="Speract-like 3"
FT                   /id="PRO_0000022280"
FT   PROPEP          290..296
FT                   /id="PRO_0000278271"
SQ   SEQUENCE   296 AA;  30647 MW;  6B7F7484A255FDC4 CRC64;
     MPPGPRGVAS GKPVISGQDQ KYTLADSSKD LEGIAHMAIV DSLSPLHISL SSLESAWNNL
     LNIASQEDYS IPELSIPKID VKSILSCKPK YSPKYPVVLQ YISDHYVQVQ DHIANAKELT
     EGLKFVSQLI MYKKIDHDTL ASVSKMLSNY LTDYASTISS LKSVVCQDQT APSHPMDESY
     MDTPLSMILK GTMPTGAGVD KGFALGGGGV GKGFNLNGGG VGKGFDLNGG GVGKGFDLNG
     GGVGKGFDLN GGGVGKGFDL NGGGVGKGFA LGGGGVGKGF SLTGGGVGRE VEIKDW