ID   SAR1A_PONAB             Reviewed;         198 AA.
AC   Q5R548;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=GTP-binding protein SAR1a;
GN   Name=SAR1A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in transport from the endoplasmic reticulum to the
CC       Golgi apparatus. Required to maintain SEC16A localization at discrete
CC       locations on the ER membrane perhaps by preventing its dissociation.
CC       SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an
CC       organized scaffold defining endoplasmic reticulum exit sites (ERES) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with B3GAT1. {ECO:0000250|UniProtKB:Q9NR31}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi
CC       apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. SAR1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR861024; CAH93118.1; -; mRNA.
DR   RefSeq; NP_001126844.1; NM_001133372.1.
DR   RefSeq; XP_009243799.1; XM_009245524.1.
DR   RefSeq; XP_009243800.1; XM_009245525.1.
DR   AlphaFoldDB; Q5R548; -.
DR   SMR; Q5R548; -.
DR   STRING; 9601.ENSPPYP00000002755; -.
DR   Ensembl; ENSPPYT00000002849; ENSPPYP00000002755; ENSPPYG00000002374.
DR   GeneID; 100173852; -.
DR   KEGG; pon:100173852; -.
DR   CTD; 56681; -.
DR   eggNOG; KOG0077; Eukaryota.
DR   GeneTree; ENSGT00940000155276; -.
DR   HOGENOM; CLU_040729_6_0_1; -.
DR   InParanoid; Q5R548; -.
DR   OMA; DDRIAQH; -.
DR   OrthoDB; 1168548at2759; -.
DR   TreeFam; TF312890; -.
DR   Proteomes; UP000001595; Chromosome 10.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   InterPro; IPR006687; Small_GTPase_SAR1.
DR   PANTHER; PTHR45684; PTHR45684; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51422; SAR1; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding;
KW   Nucleotide-binding; Phosphoprotein; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..198
FT                   /note="GTP-binding protein SAR1a"
FT                   /id="PRO_0000249777"
FT   BINDING         32..39
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         139
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR31"
SQ   SEQUENCE   198 AA;  22367 MW;  38A869175CBA54F3 CRC64;
     MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT
     SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT
     DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV
     LKRQGYGEGF RWLSQYID