ID   SAR1_GIAIN              Reviewed;         191 AA.
AC   Q8MQT8;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=GTP-binding protein Sar1;
GN   Name=SAR1;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RA   Marti M., Hehl A.B.;
RT   "Sar1p, Giardia homolog to GTP-binding protein Sar1p.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in transport from the endoplasmic reticulum to the
CC       Golgi apparatus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi
CC       apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. SAR1 family.
CC       {ECO:0000305}.
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DR   EMBL; AY125726; AAM83404.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8MQT8; -.
DR   SMR; Q8MQT8; -.
DR   PRIDE; Q8MQT8; -.
DR   VEuPathDB; GiardiaDB:DHA2_7569; -.
DR   VEuPathDB; GiardiaDB:GL50581_2996; -.
DR   VEuPathDB; GiardiaDB:GL50803_007569; -.
DR   eggNOG; KOG0077; Eukaryota.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   InterPro; IPR006687; Small_GTPase_SAR1.
DR   PANTHER; PTHR45684; PTHR45684; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51422; SAR1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding;
KW   Nucleotide-binding; Protein transport; Transport.
FT   CHAIN           1..191
FT                   /note="GTP-binding protein Sar1"
FT                   /id="PRO_0000206264"
FT   BINDING         27..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..73
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         129..132
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   191 AA;  21248 MW;  D56F42C10A971544 CRC64;
     MGFGDWFKSA LSFLGLYKKK ATIVFVGLDN AGKSTLLAML KNSATTTVAP TQQPTSQELV
     MGSIRFKTFD LGGHEVARQL WEQYVTNSDG IVFLVDSADP SRFEESRRTL QELLDNHDLA
     TTPILILSNK VDIQTAVSME TMVQSFGIQH LLTGKGGSNL RSDQRPLEVF PCSVINRFGY
     TDGFKWLSKY L