SARD4_ARATH
ID SARD4_ARATH Reviewed; 325 AA.
AC Q9FLY0; Q84W61; Q8LFS5;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Protein SAR DEFICIENT 4 {ECO:0000303|PubMed:27758894};
DE AltName: Full=Ornithine cyclodeaminase-like protein {ECO:0000305};
DE Short=AtOCD {ECO:0000303|PubMed:24237637};
DE Flags: Precursor;
GN Name=SARD4 {ECO:0000303|PubMed:27758894};
GN Synonyms=OCD {ECO:0000303|PubMed:24237637};
GN OrderedLocusNames=At5g52810 {ECO:0000312|Araport:AT5G52810};
GN ORFNames=MXC20.2 {ECO:0000312|EMBL:AED96264.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24237637; DOI=10.1186/1471-2229-13-182;
RA Sharma S., Shinde S., Verslues P.E.;
RT "Functional characterization of an ornithine cyclodeaminase-like protein of
RT Arabidopsis thaliana.";
RL BMC Plant Biol. 13:182-182(2013).
RN [7]
RP FUNCTION, INDUCTION BY PSEUDOMONAS SYRINGAE PV MACULICOLA, DISRUPTION
RP PHENOTYPE, AND MUTAGENESIS OF GLY-89; GLY-138 AND SER-205.
RX PubMed=27758894; DOI=10.1105/tpc.16.00486;
RA Ding P., Rekhter D., Ding Y., Feussner K., Busta L., Haroth S., Xu S.,
RA Li X., Jetter R., Feussner I., Zhang Y.;
RT "Characterization of a pipecolic acid biosynthesis pathway required for
RT systemic acquired resistance.";
RL Plant Cell 28:2603-2615(2016).
CC -!- FUNCTION: Involved in the biosynthesis of pipecolate (Pip), a
CC metabolite that orchestrates defense amplification, positive regulation
CC of salicylic acid (SA) biosynthesis, and priming to guarantee effective
CC local resistance induction and the establishment of systemic acquired
CC resistance (SAR). Converts delta-(1)-piperideine-2-carboxylate (P2C) to
CC Pip. Mediates reduction of P2C and biosynthesis of Pip in systemic
CC tissue and contributes to SAR establishment (PubMed:27758894). Does not
CC possess ornithine cyclodeaminase activity in vitro (PubMed:24237637).
CC {ECO:0000269|PubMed:24237637, ECO:0000269|PubMed:27758894}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:24237637}.
CC -!- INDUCTION: Induced by Pseudomonas syringae pv. maculicola
CC (PubMed:27758894). Induced by low water potential stress and treatment
CC with exogenous proline (PubMed:24237637). {ECO:0000269|PubMed:24237637,
CC ECO:0000269|PubMed:27758894}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions (PubMed:24237637, PubMed:27758894). Mutant plants have
CC compromised systemic acquired resistance (SAR) (PubMed:27758894).
CC Mutant seedlings accumulate increased levels of proline
CC (PubMed:24237637). {ECO:0000269|PubMed:24237637,
CC ECO:0000269|PubMed:27758894}.
CC -!- SIMILARITY: Belongs to the ornithine cyclodeaminase/mu-crystallin
CC family. {ECO:0000305}.
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DR EMBL; AB009055; BAB10429.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96264.1; -; Genomic_DNA.
DR EMBL; BT004199; AAO42217.1; -; mRNA.
DR EMBL; BT020531; AAW52557.1; -; mRNA.
DR EMBL; BT021995; AAY25407.1; -; mRNA.
DR EMBL; AY084671; AAM61233.1; -; mRNA.
DR RefSeq; NP_200093.1; NM_124659.2.
DR AlphaFoldDB; Q9FLY0; -.
DR SMR; Q9FLY0; -.
DR STRING; 3702.AT5G52810.1; -.
DR iPTMnet; Q9FLY0; -.
DR PaxDb; Q9FLY0; -.
DR PRIDE; Q9FLY0; -.
DR ProteomicsDB; 226643; -.
DR EnsemblPlants; AT5G52810.1; AT5G52810.1; AT5G52810.
DR GeneID; 835358; -.
DR Gramene; AT5G52810.1; AT5G52810.1; AT5G52810.
DR KEGG; ath:AT5G52810; -.
DR Araport; AT5G52810; -.
DR TAIR; locus:2176882; AT5G52810.
DR eggNOG; KOG3007; Eukaryota.
DR HOGENOM; CLU_042088_1_2_1; -.
DR InParanoid; Q9FLY0; -.
DR OMA; AVKAFTY; -.
DR OrthoDB; 1345495at2759; -.
DR PhylomeDB; Q9FLY0; -.
DR PRO; PR:Q9FLY0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLY0; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009536; C:plastid; IDA:TAIR.
DR GO; GO:0062046; F:dehydropipecolic acid reductase; IMP:TAIR.
DR GO; GO:0062034; P:L-pipecolic acid biosynthetic process; IMP:TAIR.
DR GO; GO:1901672; P:positive regulation of systemic acquired resistance; IMP:UniProtKB.
DR GO; GO:0009627; P:systemic acquired resistance; IDA:TAIR.
DR Gene3D; 3.30.1780.10; -; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003462; ODC_Mu_crystall.
DR InterPro; IPR023401; ODC_N.
DR PANTHER; PTHR13812; PTHR13812; 1.
DR Pfam; PF02423; OCD_Mu_crystall; 1.
DR PIRSF; PIRSF001439; CryM; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Plant defense; Plastid; Reference proteome; Transit peptide.
FT TRANSIT 1..42
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 43..325
FT /note="Protein SAR DEFICIENT 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000441128"
FT MUTAGEN 89
FT /note="G->E: In sard4-3; compromises systemic acquired
FT resistance (SAR)."
FT /evidence="ECO:0000269|PubMed:27758894"
FT MUTAGEN 138
FT /note="G->D: In sard4-4; compromises systemic acquired
FT resistance (SAR)."
FT /evidence="ECO:0000269|PubMed:27758894"
FT MUTAGEN 205
FT /note="S->N: In sard4-1; compromises systemic acquired
FT resistance (SAR)."
FT /evidence="ECO:0000269|PubMed:27758894"
FT CONFLICT 264
FT /note="A -> V (in Ref. 5; AAM61233)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="D -> G (in Ref. 3; AAO42217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35223 MW; 956B200C44A3F332 CRC64;
MAALPVFIPA ESFPSILSHE TLINHFRTNL PKHSSTITSP VRQNYTVSSP SSLLLMPSWS
SSSSLPYMGV KLVTYFPHNS SQNLPGIHGS YTLFSSTTGQ TLATMDGTVL TLYRTSSVSG
LGSKILARDD SQVLIMVGSG ALAPHLIKSH LAAKPSLRRV IIWNRTPQRA QELAETLSKD
PQHKEISFDS HDSLDQIIPL GDIISCATNS TVPLVKGEFL KPGTHLDLVG SFSHEMKECD
DNAIQRGSVF VDNDTAMIEA GELAGAFERG VIKREDICGN LVELIKGDKE GRKSSTDITV
FKSVGSGTVD LLTAQLVHET YLSRC
