SARG_MOUSE
ID SARG_MOUSE Reviewed; 606 AA.
AC Q8BI29; A2VDH0; Q4FZK7; Q8BHU5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Specifically androgen-regulated gene protein;
GN Name=Sarg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Skin, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-334; SER-397; SER-412 AND
RP SER-524, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative androgen-specific receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BI29-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BI29-2; Sequence=VSP_031229;
CC -!- SIMILARITY: Belongs to the SARG family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK028957; BAC26213.1; -; mRNA.
DR EMBL; AK085225; BAC39393.1; -; mRNA.
DR EMBL; BC099401; AAH99401.1; -; mRNA.
DR EMBL; BC117765; AAI17766.1; -; mRNA.
DR EMBL; BC117766; AAI17767.1; -; mRNA.
DR EMBL; BC129960; AAI29961.1; -; mRNA.
DR CCDS; CCDS48352.1; -. [Q8BI29-1]
DR RefSeq; NP_808272.2; NM_177604.3. [Q8BI29-1]
DR RefSeq; XP_017175106.1; XM_017319617.1. [Q8BI29-2]
DR AlphaFoldDB; Q8BI29; -.
DR STRING; 10090.ENSMUSP00000046172; -.
DR iPTMnet; Q8BI29; -.
DR PhosphoSitePlus; Q8BI29; -.
DR MaxQB; Q8BI29; -.
DR PaxDb; Q8BI29; -.
DR PeptideAtlas; Q8BI29; -.
DR PRIDE; Q8BI29; -.
DR ProteomicsDB; 256835; -. [Q8BI29-1]
DR ProteomicsDB; 256836; -. [Q8BI29-2]
DR Antibodypedia; 1991; 71 antibodies from 20 providers.
DR DNASU; 212439; -.
DR Ensembl; ENSMUST00000039323; ENSMUSP00000046172; ENSMUSG00000042510. [Q8BI29-1]
DR GeneID; 212439; -.
DR KEGG; mmu:212439; -.
DR UCSC; uc007cmi.2; mouse. [Q8BI29-1]
DR MGI; MGI:2138143; AA986860.
DR VEuPathDB; HostDB:ENSMUSG00000042510; -.
DR eggNOG; ENOG502RGW5; Eukaryota.
DR GeneTree; ENSGT00390000017874; -.
DR HOGENOM; CLU_035136_0_0_1; -.
DR InParanoid; Q8BI29; -.
DR OMA; NSHTPGE; -.
DR OrthoDB; 484727at2759; -.
DR PhylomeDB; Q8BI29; -.
DR TreeFam; TF336615; -.
DR BioGRID-ORCS; 212439; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BI29; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BI29; protein.
DR Bgee; ENSMUSG00000042510; Expressed in epithelium of small intestine and 135 other tissues.
DR Genevisible; Q8BI29; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR InterPro; IPR026152; SARG.
DR PANTHER; PTHR21555; PTHR21555; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Receptor;
KW Reference proteome.
FT CHAIN 1..606
FT /note="Specifically androgen-regulated gene protein"
FT /id="PRO_0000318576"
FT REGION 64..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW04"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BW04"
FT MOD_RES 334
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 397
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 412
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 524
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..245
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031229"
FT CONFLICT 264
FT /note="L -> P (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="Q -> E (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="S -> N (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 381
FT /note="A -> T (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 414
FT /note="K -> M (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 424
FT /note="S -> N (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 452
FT /note="L -> S (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 458
FT /note="R -> Q (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 492
FT /note="V -> I (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="G -> R (in Ref. 1; BAC39393)"
FT /evidence="ECO:0000305"
FT CONFLICT 517
FT /note="S -> G (in Ref. 2; AAI29961)"
FT /evidence="ECO:0000305"
FT CONFLICT 560
FT /note="C -> F (in Ref. 1; BAC26213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 65092 MW; 22E257F64504E3A6 CRC64;
MPKRELWPAG LCSEPVTHIG SCGDMMSTTS TRSGSSDSSY DFLSAEEKEC LLFLEKTIGS
LEAEADSGLS TDESEPATSP RSFRALPTAT QQAPQGKPEA TDIQQVPVPK RVAQPSCPPE
SHSLGLRAGS YSLPRNLHLG RSQNLRESAT QANSPVSEAS EVFLEEPEKG QTSQGAKAKT
IQPPAPSQKG TLDLSTVLIP PPEAFQDIRP KESGEESPPK KPGEQTHTPQ VHSLERSPHS
QKKVEMSSET VSHKATEKGW TEGLQQPQQP PAQSSQPTKA EELSLPSGVK PSIQQTPLTA
SKARKLPPNI VLKSSRSSFH SHPQNWLSNH TEATDSGPVS SLQEQRKARR EALEKLGLPQ
DQDDPSLLVN KHTSTLKVRE AQPQTPSQAR APARPASPAL VSGTASAAGK VSPKKAVAPM
DSLSKGWIPT QETPPGKVAE AKSMPIPIPK TLKENSSRTQ PKPDPRLTLQ ESSIPGLRQM
NFKSNTLERS GVGLSSYLSA AEKKDPSCQT STSLGKSPFL DKVSPSAFRN SRPRPASLGM
GKDFAGIQGG KLVGLEQDQC SQQPSFKGQS YDKLPRPPCI SVKISPKGIP DGHRREALKK
LGLLKE
