ID   SARR_STAA3              Reviewed;         115 AA.
AC   Q2FEJ8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator SarR;
DE   AltName: Full=Staphylococcal accessory regulator R;
GN   Name=sarR; OrderedLocusNames=SAUSA300_2245;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Negative regulator of sarA transcription at late exponential
CC       and stationary growth phases. It contributes to the modulation of
CC       target genes downstream of the sarA regulatory cascade. Also,
CC       positively regulates expression of primary transcripts RNAII and RNAIII
CC       generated by agr (virulence accessory gene regulator) locus (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD20487.1; -; Genomic_DNA.
DR   RefSeq; WP_000036076.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FEJ8; -.
DR   SMR; Q2FEJ8; -.
DR   EnsemblBacteria; ABD20487; ABD20487; SAUSA300_2245.
DR   KEGG; saa:SAUSA300_2245; -.
DR   HOGENOM; CLU_164084_0_0_9; -.
DR   OMA; HDERTVI; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..115
FT                   /note="HTH-type transcriptional regulator SarR"
FT                   /id="PRO_0000240488"
FT   DNA_BIND        51..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13669 MW;  D2CE40E2DB234DBD CRC64;
     MSKINDINDL VNATFQVKKF FRDTKKKFNL NYEEIYILNH ILRSESNEIS SKEIAKCSEF
     KPYYLTKALQ KLKDLKLLSK KRSLQDERTV IVYVTDTQKA NIQKLISELE EYIKN