SARR_STAAB
ID SARR_STAAB Reviewed; 115 AA.
AC Q2YYV0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=HTH-type transcriptional regulator SarR;
DE AltName: Full=Staphylococcal accessory regulator R;
GN Name=sarR; OrderedLocusNames=SAB2167c;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Negative regulator of sarA transcription at late exponential
CC and stationary growth phases. It contributes to the modulation of
CC target genes downstream of the sarA regulatory cascade. Also,
CC positively regulates expression of primary transcripts RNAII and RNAIII
CC generated by agr (virulence accessory gene regulator) locus (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR EMBL; AJ938182; CAI81856.1; -; Genomic_DNA.
DR RefSeq; WP_000036076.1; NC_007622.1.
DR AlphaFoldDB; Q2YYV0; -.
DR SMR; Q2YYV0; -.
DR KEGG; sab:SAB2167c; -.
DR HOGENOM; CLU_164084_0_0_9; -.
DR OMA; HDERTVI; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR010166; SarA/Rot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW Transcription regulation; Virulence.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..115
FT /note="HTH-type transcriptional regulator SarR"
FT /id="PRO_0000240487"
FT DNA_BIND 51..74
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 115 AA; 13669 MW; D2CE40E2DB234DBD CRC64;
MSKINDINDL VNATFQVKKF FRDTKKKFNL NYEEIYILNH ILRSESNEIS SKEIAKCSEF
KPYYLTKALQ KLKDLKLLSK KRSLQDERTV IVYVTDTQKA NIQKLISELE EYIKN