ID   SARR_STAAC              Reviewed;         115 AA.
AC   Q5HDR3;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=HTH-type transcriptional regulator SarR;
DE   AltName: Full=Staphylococcal accessory regulator R;
GN   Name=sarR; OrderedLocusNames=SACOL2287;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Negative regulator of sarA transcription at late exponential
CC       and stationary growth phases. It contributes to the modulation of
CC       target genes downstream of the sarA regulatory cascade. Also,
CC       positively regulates expression of primary transcripts RNAII and RNAIII
CC       generated by agr (virulence accessory gene regulator) locus (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW38507.1; -; Genomic_DNA.
DR   RefSeq; WP_000036076.1; NC_002951.2.
DR   AlphaFoldDB; Q5HDR3; -.
DR   SMR; Q5HDR3; -.
DR   EnsemblBacteria; AAW38507; AAW38507; SACOL2287.
DR   KEGG; sac:SACOL2287; -.
DR   HOGENOM; CLU_164084_0_0_9; -.
DR   OMA; HDERTVI; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..115
FT                   /note="HTH-type transcriptional regulator SarR"
FT                   /id="PRO_0000219584"
FT   DNA_BIND        51..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13669 MW;  D2CE40E2DB234DBD CRC64;
     MSKINDINDL VNATFQVKKF FRDTKKKFNL NYEEIYILNH ILRSESNEIS SKEIAKCSEF
     KPYYLTKALQ KLKDLKLLSK KRSLQDERTV IVYVTDTQKA NIQKLISELE EYIKN