ID   SARR_STAAN              Reviewed;         115 AA.
AC   Q7A425;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=HTH-type transcriptional regulator SarR;
DE   AltName: Full=Staphylococcal accessory regulator R;
GN   Name=sarR; OrderedLocusNames=SA2089;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Negative regulator of sarA transcription at late exponential
CC       and stationary growth phases. It contributes to the modulation of
CC       target genes downstream of the sarA regulatory cascade. Also,
CC       positively regulates expression of primary transcripts RNAII and RNAIII
CC       generated by agr (virulence accessory gene regulator) locus (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43387.1; -; Genomic_DNA.
DR   PIR; B90028; B90028.
DR   RefSeq; WP_000036076.1; NC_002745.2.
DR   AlphaFoldDB; Q7A425; -.
DR   SMR; Q7A425; -.
DR   EnsemblBacteria; BAB43387; BAB43387; BAB43387.
DR   KEGG; sau:SA2089; -.
DR   HOGENOM; CLU_164084_0_0_9; -.
DR   OMA; HDERTVI; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..115
FT                   /note="HTH-type transcriptional regulator SarR"
FT                   /id="PRO_0000219586"
FT   DNA_BIND        51..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13669 MW;  D2CE40E2DB234DBD CRC64;
     MSKINDINDL VNATFQVKKF FRDTKKKFNL NYEEIYILNH ILRSESNEIS SKEIAKCSEF
     KPYYLTKALQ KLKDLKLLSK KRSLQDERTV IVYVTDTQKA NIQKLISELE EYIKN