ID   SARS_STAAE              Reviewed;         250 AA.
AC   A6QD96;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=HTH-type transcriptional regulator SarS;
DE   AltName: Full=Staphylococcal accessory regulator S;
GN   Name=sarS; OrderedLocusNames=NWMN_0056;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   REGULATION BY MGRA.
RX   PubMed=15731040; DOI=10.1128/iai.73.3.1423-1431.2005;
RA   Ingavale S.S., van Wamel W., Luong T.T., Lee C.Y., Cheung A.L.;
RT   "Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in
RT   Staphylococcus aureus.";
RL   Infect. Immun. 73:1423-1431(2005).
CC   -!- FUNCTION: Transcriptional regulator that controls expression of some
CC       virulence factors in a cell density-dependent manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Expressed at the early exponential growth phase, decreases
CC       through exponential phase and reaches a steady-state level at post-
CC       exponential phase. Repressed by MgrA and SarA. Activated by Rot and
CC       SarT. Transcription is also dependent on SigA and SigB factors. Is
CC       activated by SigB in strains harboring an intact sigB operon (rsbU,
CC       rsbV, rsbW, and sigB) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF66328.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP009351; BAF66328.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000876756.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QD96; -.
DR   SMR; A6QD96; -.
DR   EnsemblBacteria; BAF66328; BAF66328; NWMN_0056.
DR   KEGG; sae:NWMN_0056; -.
DR   HOGENOM; CLU_097164_0_0_9; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SMART; SM00347; HTH_MARR; 2.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="HTH-type transcriptional regulator SarS"
FT                   /id="PRO_0000324107"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        177..200
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  29890 MW;  4680D50FE86DDC19 CRC64;
     MKYNNHDKIR DFIIIEAYMF RFKKKVKPEV DMTIKEFILL TYLFHQQENT LPFKKIVSDL
     CYKQSDLVQH IKVLVKHSYI SKVRSKIDER NTYISISEEQ REKIAERVTL FDQIIKQFNL
     ADQSESQMIP KDSKEFLNLM MYTMYFKNII KKHLTLSFVE FTILAIITSQ NKNIVLLKDL
     IETIHHKYPQ TVRALNNLKK QGYLIKERST EDERKILIHM DDAQQDHAEQ LLAQVNQLLA
     DKDHLHLVFE