ID   SARS_STAAN              Reviewed;         250 AA.
AC   Q7A872; Q9KWJ2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=HTH-type transcriptional regulator SarS;
DE   AltName: Full=Staphylococcal accessory regulator S;
GN   Name=sarS; Synonyms=sarH1; OrderedLocusNames=SA0108;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kuroda-Murakami H., Kuroda M., Hiramatsu K.;
RT   "Identification of differentially expressed genes of Staphylococcus aureus
RT   in response to and in raised resistance to imipenem.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Transcriptional regulator that controls expression of some
CC       virulence factors in a cell density-dependent manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; AB050858; BAB69826.1; -; Genomic_DNA.
DR   EMBL; BA000018; BAB41327.1; -; Genomic_DNA.
DR   PIR; D89771; D89771.
DR   RefSeq; WP_000876756.1; NC_002745.2.
DR   AlphaFoldDB; Q7A872; -.
DR   SMR; Q7A872; -.
DR   EnsemblBacteria; BAB41327; BAB41327; BAB41327.
DR   KEGG; sau:SA0108; -.
DR   HOGENOM; CLU_097164_0_0_9; -.
DR   OMA; DHIIKQF; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SMART; SM00347; HTH_MARR; 2.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..250
FT                   /note="HTH-type transcriptional regulator SarS"
FT                   /id="PRO_0000219593"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        177..200
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  29890 MW;  4680D50FE86DDC19 CRC64;
     MKYNNHDKIR DFIIIEAYMF RFKKKVKPEV DMTIKEFILL TYLFHQQENT LPFKKIVSDL
     CYKQSDLVQH IKVLVKHSYI SKVRSKIDER NTYISISEEQ REKIAERVTL FDQIIKQFNL
     ADQSESQMIP KDSKEFLNLM MYTMYFKNII KKHLTLSFVE FTILAIITSQ NKNIVLLKDL
     IETIHHKYPQ TVRALNNLKK QGYLIKERST EDERKILIHM DDAQQDHAEQ LLAQVNQLLA
     DKDHLHLVFE