ID   SART_STAAC              Reviewed;         118 AA.
AC   Q5HD56;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=HTH-type transcriptional regulator SarT;
DE   AltName: Full=Staphylococcal accessory regulator T;
GN   Name=sarT; Synonyms=sarH3; OrderedLocusNames=SACOL2506;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Transcriptional regulator acting as an intermediary between
CC       major regulators SarA and agr and virulence genes. Represses alpha-
CC       hemolysin (hla) gene expression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW37285.1; -; Genomic_DNA.
DR   RefSeq; WP_000998869.1; NC_002951.2.
DR   AlphaFoldDB; Q5HD56; -.
DR   SMR; Q5HD56; -.
DR   EnsemblBacteria; AAW37285; AAW37285; SACOL2506.
DR   KEGG; sac:SACOL2506; -.
DR   HOGENOM; CLU_2095348_0_0_9; -.
DR   OMA; MRDVITY; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..118
FT                   /note="HTH-type transcriptional regulator SarT"
FT                   /id="PRO_0000219597"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   118 AA;  13988 MW;  231D70A48079ECF7 CRC64;
     MNDLKSKSNI KLMKRVLTTY ELRKYLKKYF CLTLDNYLVL AYLDVFKNDE GKYFMRDIIS
     YIGIDQSRIV KSVKDLSKKG YLNKCRDPHD SRNVIIVVSV KQHNYIKNLL SEININET