ID   SART_STAAM              Reviewed;         118 AA.
AC   Q99RD6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator SarT;
DE   AltName: Full=Staphylococcal accessory regulator T;
GN   Name=sarT; Synonyms=sarH3; OrderedLocusNames=SAV2498;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Transcriptional regulator acting as an intermediary between
CC       major regulators SarA and agr and virulence genes. Represses alpha-
CC       hemolysin (hla) gene expression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB58660.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB58660.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000998872.1; NC_002758.2.
DR   AlphaFoldDB; Q99RD6; -.
DR   SMR; Q99RD6; -.
DR   PaxDb; Q99RD6; -.
DR   EnsemblBacteria; BAB58660; BAB58660; SAV2498.
DR   KEGG; sav:SAV2498; -.
DR   HOGENOM; CLU_2095348_0_0_9; -.
DR   OMA; MRDVITY; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..118
FT                   /note="HTH-type transcriptional regulator SarT"
FT                   /id="PRO_0000219598"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   118 AA;  14002 MW;  231D70A5D13CF9F7 CRC64;
     MNDLKSKSNI KLMKRVLTTY ELRKYLKKYF CLTLDNYLVL AYLDVFKNDE GKYFMRDIIS
     YIGIDQSRIV KSVKELSKKG YLNKCRDPHD SRNVIIVVSV KQHNYIKNLL SEININET