ID   SARU_STAA8              Reviewed;         247 AA.
AC   Q2G1T7;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=HTH-type transcriptional regulator SarU;
DE   AltName: Full=Staphylococcal accessory regulator U;
GN   Name=sarU; OrderedLocusNames=SAOUHSC_02800;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION, AND REGULATION BY SART.
RX   PubMed=12496184; DOI=10.1128/iai.71.1.343-353.2003;
RA   Manna A.C., Cheung A.L.;
RT   "sarU, a sarA homolog, is repressed by SarT and regulates virulence genes
RT   in Staphylococcus aureus.";
RL   Infect. Immun. 71:343-353(2003).
CC   -!- FUNCTION: Positive regulator of RNAII and RNAIII in a cell density-
CC       dependent manner. It can contribute to the expression of virulence
CC       genes controlled by agr. May also regulate target genes via an agr-
CC       independent pathway. {ECO:0000269|PubMed:12496184}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Maximally expressed during post-exponential growth phase.
CC       Repressed by SarT.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000253; ABD31803.1; -; Genomic_DNA.
DR   RefSeq; WP_000386367.1; NZ_LS483365.1.
DR   RefSeq; YP_501259.1; NC_007795.1.
DR   AlphaFoldDB; Q2G1T7; -.
DR   SMR; Q2G1T7; -.
DR   STRING; 1280.SAXN108_2746; -.
DR   EnsemblBacteria; ABD31803; ABD31803; SAOUHSC_02800.
DR   GeneID; 3921454; -.
DR   KEGG; sao:SAOUHSC_02800; -.
DR   PATRIC; fig|93061.5.peg.2532; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_097164_0_0_9; -.
DR   OMA; CILISIN; -.
DR   PRO; PR:Q2G1T7; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..247
FT                   /note="HTH-type transcriptional regulator SarU"
FT                   /id="PRO_0000249331"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        178..201
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  29793 MW;  90AE3B0F7A87CC35 CRC64;
     MDYQTFEKVN KFINVEAYIF FLTQELKQQY KLSLKELLIL AYFYYKNEHS ISLKEIIGDI
     LYKQSDVVKN IKSLSKKGFI NKSRNEADER RIFVSVTPIQ RKKIACVINE LDKIIKGFNK
     ERDYIKYQWA PKYSKEFFIL FMNIMYSKDF LKYRFNLTFL DLSILYVISS RKNEILNLKD
     LFESIRFMYP QIVRSVNRLN NKGMLIKERS LADERIVLIK INKIQYNTIK SIFTDTSKIL
     KPRKFFF