ID   SARU_STAAM              Reviewed;         247 AA.
AC   Q99RD5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=HTH-type transcriptional regulator SarU;
DE   AltName: Full=Staphylococcal accessory regulator U;
GN   Name=sarU; Synonyms=sarH2; OrderedLocusNames=SAV2499;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Positive regulator of RNAII and RNAIII in a cell density-
CC       dependent manner. It can contribute to the expression of virulence
CC       genes controlled by agr. May also regulate target genes via an agr-
CC       independent pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58661.1; -; Genomic_DNA.
DR   RefSeq; WP_000386367.1; NC_002758.2.
DR   AlphaFoldDB; Q99RD5; -.
DR   SMR; Q99RD5; -.
DR   PaxDb; Q99RD5; -.
DR   EnsemblBacteria; BAB58661; BAB58661; SAV2499.
DR   KEGG; sav:SAV2499; -.
DR   HOGENOM; CLU_097164_0_0_9; -.
DR   OMA; CILISIN; -.
DR   PhylomeDB; Q99RD5; -.
DR   BioCyc; SAUR158878:SAV_RS13630-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..247
FT                   /note="HTH-type transcriptional regulator SarU"
FT                   /id="PRO_0000219604"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        178..201
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  29793 MW;  90AE3B0F7A87CC35 CRC64;
     MDYQTFEKVN KFINVEAYIF FLTQELKQQY KLSLKELLIL AYFYYKNEHS ISLKEIIGDI
     LYKQSDVVKN IKSLSKKGFI NKSRNEADER RIFVSVTPIQ RKKIACVINE LDKIIKGFNK
     ERDYIKYQWA PKYSKEFFIL FMNIMYSKDF LKYRFNLTFL DLSILYVISS RKNEILNLKD
     LFESIRFMYP QIVRSVNRLN NKGMLIKERS LADERIVLIK INKIQYNTIK SIFTDTSKIL
     KPRKFFF