ID   SARU_STAAU              Reviewed;         247 AA.
AC   Q9EZK4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=HTH-type transcriptional regulator SarU;
DE   AltName: Full=Staphylococcal accessory regulator U;
GN   Name=sarU; Synonyms=rlp, sarH2;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   McNamara P.J., Milligan-Monroe K., Proctor R.A.;
RT   "The isolation and characterization of rlp, an activator of the
RT   Staphylococcus aureus virulence factor regulator pathway encoded by agr.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positive regulator of RNAII and RNAIII in a cell density-
CC       dependent manner. It can contribute to the expression of virulence
CC       genes controlled by agr. May also regulate target genes via an agr-
CC       independent pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; AF288788; AAG45334.2; -; Genomic_DNA.
DR   RefSeq; WP_000386369.1; NZ_UHCI01000002.1.
DR   AlphaFoldDB; Q9EZK4; -.
DR   SMR; Q9EZK4; -.
DR   PATRIC; fig|1280.3350.peg.2433; -.
DR   OMA; CILISIN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..247
FT                   /note="HTH-type transcriptional regulator SarU"
FT                   /id="PRO_0000219602"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        178..201
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  29792 MW;  D078366866F60B2B CRC64;
     MDYQTFEKVN KFINVKAYIF FLTQELKQQY KLSLKELLIL AYFYYKNEHS ISLKEIIGDI
     LYKQSDVVKN IKSLSKKGFI NKSRNEADER RIFVSVTPIQ RKKIACVINE LDKIIKGFNK
     ERDYIKYQWA PKYSKEFFIL FMNIMYSKDF LKYRFNLTFL DLSILYVISS RKNEILNLKD
     LFESIRFMYP QIVRSVNRLN NKGMLIKERS LADERIVLIK INKIQYNTIK SIFTDTSKIL
     KPRKFFF