ID   SARU_STAAW              Reviewed;         247 AA.
AC   Q7A004;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional regulator SarU;
DE   AltName: Full=Staphylococcal accessory regulator U;
GN   Name=sarU; Synonyms=sarH2; OrderedLocusNames=MW2418;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Positive regulator of RNAII and RNAIII in a cell density-
CC       dependent manner. It can contribute to the expression of virulence
CC       genes controlled by agr. May also regulate target genes via an agr-
CC       independent pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB96283.1; -; Genomic_DNA.
DR   RefSeq; WP_000386367.1; NC_003923.1.
DR   AlphaFoldDB; Q7A004; -.
DR   SMR; Q7A004; -.
DR   EnsemblBacteria; BAB96283; BAB96283; BAB96283.
DR   KEGG; sam:MW2418; -.
DR   HOGENOM; CLU_097164_0_0_9; -.
DR   OMA; CILISIN; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13463; HTH_27; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 2.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..247
FT                   /note="HTH-type transcriptional regulator SarU"
FT                   /id="PRO_0000219607"
FT   DNA_BIND        53..76
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        178..201
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  29793 MW;  90AE3B0F7A87CC35 CRC64;
     MDYQTFEKVN KFINVEAYIF FLTQELKQQY KLSLKELLIL AYFYYKNEHS ISLKEIIGDI
     LYKQSDVVKN IKSLSKKGFI NKSRNEADER RIFVSVTPIQ RKKIACVINE LDKIIKGFNK
     ERDYIKYQWA PKYSKEFFIL FMNIMYSKDF LKYRFNLTFL DLSILYVISS RKNEILNLKD
     LFESIRFMYP QIVRSVNRLN NKGMLIKERS LADERIVLIK INKIQYNTIK SIFTDTSKIL
     KPRKFFF