ID   SARV_STAA8              Reviewed;         116 AA.
AC   Q2FVY9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=HTH-type transcriptional regulator SarV;
DE   AltName: Full=Staphylococcal accessory regulator V;
GN   Name=sarV; OrderedLocusNames=SAOUHSC_02532;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=15292128; DOI=10.1128/jb.186.16.5267-5280.2004;
RA   Manna A.C., Ingavale S.S., Maloney M., van Wamel W., Cheung A.L.;
RT   "Identification of sarV (SA2062), a new transcriptional regulator, is
RT   repressed by SarA and MgrA (SA0641) and involved in the regulation of
RT   autolysis in Staphylococcus aureus.";
RL   J. Bacteriol. 186:5267-5280(2004).
CC   -!- FUNCTION: Part of the pathway by which MgrA and SarA control autolysis.
CC       Involved in regulation of virulence and autolysis genes such as hla,
CC       splA, aur, scp, lrgB, scdA and atl. May also act as an activator for
CC       the expression of regulatory genes agr, lytSR and ArlRS.
CC       {ECO:0000269|PubMed:15292128}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Repressed by SarA and MgrA by binding to the sarV promoter
CC       region.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31547.1; -; Genomic_DNA.
DR   RefSeq; WP_000066900.1; NZ_LS483365.1.
DR   RefSeq; YP_500996.1; NC_007795.1.
DR   AlphaFoldDB; Q2FVY9; -.
DR   SMR; Q2FVY9; -.
DR   STRING; 1280.SAXN108_2516; -.
DR   EnsemblBacteria; ABD31547; ABD31547; SAOUHSC_02532.
DR   GeneID; 3921122; -.
DR   KEGG; sao:SAOUHSC_02532; -.
DR   PATRIC; fig|93061.5.peg.2284; -.
DR   eggNOG; ENOG503057D; Bacteria.
DR   HOGENOM; CLU_2095367_0_0_9; -.
DR   OMA; QVFYFFN; -.
DR   PRO; PR:Q2FVY9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..116
FT                   /note="HTH-type transcriptional regulator SarV"
FT                   /id="PRO_0000249332"
FT   DNA_BIND        51..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   116 AA;  13986 MW;  CE7ACED821E33EF9 CRC64;
     MSNKVQRFIE AERELSQLKH WLKTTHKISI EEFVVLFKVY EAEKISGKEL RDTLHFEMLW
     DTSKIDVIIR KIYKKELISK LRSETDERQV FYFYSTSQKK LLDKITKEIE VLSVTN