ID   SARV_STAAC              Reviewed;         116 AA.
AC   Q5HDU2;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=HTH-type transcriptional regulator SarV;
DE   AltName: Full=Staphylococcal accessory regulator V;
GN   Name=sarV; OrderedLocusNames=SACOL2258;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Part of the pathway by which MgrA and SarA control autolysis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW37130.1; -; Genomic_DNA.
DR   RefSeq; WP_000066900.1; NC_002951.2.
DR   AlphaFoldDB; Q5HDU2; -.
DR   SMR; Q5HDU2; -.
DR   EnsemblBacteria; AAW37130; AAW37130; SACOL2258.
DR   KEGG; sac:SACOL2258; -.
DR   HOGENOM; CLU_2095367_0_0_9; -.
DR   OMA; QVFYFFN; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..116
FT                   /note="HTH-type transcriptional regulator SarV"
FT                   /id="PRO_0000219609"
FT   DNA_BIND        51..74
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   116 AA;  13986 MW;  CE7ACED821E33EF9 CRC64;
     MSNKVQRFIE AERELSQLKH WLKTTHKISI EEFVVLFKVY EAEKISGKEL RDTLHFEMLW
     DTSKIDVIIR KIYKKELISK LRSETDERQV FYFYSTSQKK LLDKITKEIE VLSVTN