SARX_STAA3
ID SARX_STAA3 Reviewed; 119 AA.
AC Q2FIX1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=HTH-type transcriptional regulator SarX;
DE AltName: Full=Staphylococcal accessory regulator X;
GN Name=sarX; OrderedLocusNames=SAUSA300_0654;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Involved in the regulation of virulence genes. Acts as a
CC repressor of the agr locus and consequently targets genes regulated by
CC the agr system such as sspA, hla and hlb. Binds directly to the agr
CC promoter region (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABD21615.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000255; ABD21615.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001090985.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FIX1; -.
DR SMR; Q2FIX1; -.
DR EnsemblBacteria; ABD21615; ABD21615; SAUSA300_0654.
DR KEGG; saa:SAUSA300_0654; -.
DR HOGENOM; CLU_166896_0_0_9; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR010166; SarA/Rot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation;
KW Virulence.
FT CHAIN 1..119
FT /note="HTH-type transcriptional regulator SarX"
FT /id="PRO_0000259137"
FT DNA_BIND 55..78
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 119 AA; 14179 MW; 6E0470B6CB2EEB94 CRC64;
MNTEKLETLL GFYKQYKALS EYIDKKYKLS LNDLAVLDLT MKHCKDEKVL MQSFLKTAMD
ELDLSRTKLL VSIRRLIEKE RLSKVRSSKD ERKIYIYLNN DDISKFNALF EDVEQFLNI