ID   SARX_STAAM              Reviewed;         119 AA.
AC   Q99VV3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator SarX;
DE   AltName: Full=Staphylococcal accessory regulator X;
GN   Name=sarX; OrderedLocusNames=SAV0668;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in the regulation of virulence genes. Acts as a
CC       repressor of the agr locus and consequently targets genes regulated by
CC       the agr system such as sspA, hla and hlb. Binds directly to the agr
CC       promoter region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB56830.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB56830.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001090985.1; NC_002758.2.
DR   AlphaFoldDB; Q99VV3; -.
DR   SMR; Q99VV3; -.
DR   PaxDb; Q99VV3; -.
DR   EnsemblBacteria; BAB56830; BAB56830; SAV0668.
DR   KEGG; sav:SAV0668; -.
DR   HOGENOM; CLU_166896_0_0_9; -.
DR   OMA; DERILMQ; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..119
FT                   /note="HTH-type transcriptional regulator SarX"
FT                   /id="PRO_0000259140"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   119 AA;  14179 MW;  6E0470B6CB2EEB94 CRC64;
     MNTEKLETLL GFYKQYKALS EYIDKKYKLS LNDLAVLDLT MKHCKDEKVL MQSFLKTAMD
     ELDLSRTKLL VSIRRLIEKE RLSKVRSSKD ERKIYIYLNN DDISKFNALF EDVEQFLNI