ID   SARX_STAAS              Reviewed;         119 AA.
AC   Q6GBG2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=HTH-type transcriptional regulator SarX;
DE   AltName: Full=Staphylococcal accessory regulator X;
GN   Name=sarX; OrderedLocusNames=SAS0633;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Involved in the regulation of virulence genes. Acts as a
CC       repressor of the agr locus and consequently targets genes regulated by
CC       the agr system such as sspA, hla and hlb. Binds directly to the agr
CC       promoter region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG42409.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX571857; CAG42409.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001090985.1; NC_002953.3.
DR   AlphaFoldDB; Q6GBG2; -.
DR   SMR; Q6GBG2; -.
DR   KEGG; sas:SAS0633; -.
DR   HOGENOM; CLU_166896_0_0_9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR010166; SarA/Rot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR01889; Staph_reg_Sar; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..119
FT                   /note="HTH-type transcriptional regulator SarX"
FT                   /id="PRO_0000259143"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   119 AA;  14179 MW;  6E0470B6CB2EEB94 CRC64;
     MNTEKLETLL GFYKQYKALS EYIDKKYKLS LNDLAVLDLT MKHCKDEKVL MQSFLKTAMD
     ELDLSRTKLL VSIRRLIEKE RLSKVRSSKD ERKIYIYLNN DDISKFNALF EDVEQFLNI