ID   SARZ_STAA3              Reviewed;         148 AA.
AC   Q2FEB2;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=HTH-type transcriptional regulator SarZ;
DE   AltName: Full=Staphylococcal accessory regulator Z;
GN   Name=sarZ; OrderedLocusNames=SAUSA300_2331;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Activates transcription of virulence factors alpha- and beta
CC       hemolysin genes (hla and hlb). Also, activates RNAIII expression, a
CC       central regulator transcribed from the agr locus (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally activated by CvfA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarZ family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000255; ABD21044.1; -; Genomic_DNA.
DR   RefSeq; WP_000289213.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FEB2; -.
DR   SMR; Q2FEB2; -.
DR   EnsemblBacteria; ABD21044; ABD21044; SAUSA300_2331.
DR   KEGG; saa:SAUSA300_2331; -.
DR   HOGENOM; CLU_083287_3_2_9; -.
DR   OMA; MMVLWER; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..148
FT                   /note="HTH-type transcriptional regulator SarZ"
FT                   /id="PRO_0000284462"
FT   DOMAIN          9..139
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   148 AA;  17435 MW;  944CA3C0F058D870 CRC64;
     MYVENSYLSK QLCFLFYVSS KEIIKKYTNY LKEYDLTYTG YIVLMAIEND EKLNIKKLGE
     RVFLDSGTLT PLLKKLEKKD YVVRTREEKD ERNLQISLTE QGKAIKSPLA EISVKVFNEF
     NISEREASDI INNLRNFVSK NFDYSDKK