ID   SARZ_STAAM              Reviewed;         148 AA.
AC   Q99RP3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=HTH-type transcriptional regulator SarZ;
DE   AltName: Full=Staphylococcal accessory regulator Z;
GN   Name=sarZ; OrderedLocusNames=SAV2386;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Activates transcription of virulence factors alpha- and beta
CC       hemolysin genes (hla and hlb). Also, activates RNAIII expression, a
CC       central regulator transcribed from the agr locus (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally activated by CvfA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarZ family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58548.1; -; Genomic_DNA.
DR   RefSeq; WP_000289215.1; NC_002758.2.
DR   AlphaFoldDB; Q99RP3; -.
DR   SMR; Q99RP3; -.
DR   PaxDb; Q99RP3; -.
DR   EnsemblBacteria; BAB58548; BAB58548; SAV2386.
DR   KEGG; sav:SAV2386; -.
DR   HOGENOM; CLU_083287_3_2_9; -.
DR   OMA; MMVLWER; -.
DR   PhylomeDB; Q99RP3; -.
DR   BioCyc; SAUR158878:SAV_RS12995-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..148
FT                   /note="HTH-type transcriptional regulator SarZ"
FT                   /id="PRO_0000284458"
FT   DOMAIN          9..139
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   148 AA;  17463 MW;  945B93C0F058D870 CRC64;
     MYVENSYLSK QLCFLFYVSS KEIIKKYTNY LKEYDLTYTG YIVLMAIEND EKLNIKKLGE
     RVFLDSGTLT PLLKKLEKKD YVVRTREEKD ERNLQISLTE QGKAIKSPLA EISVKVFNEF
     NISEREASDI INNLRNFVSK NFDYSDRK