ID   SARZ_STAEQ              Reviewed;         148 AA.
AC   Q5HLK8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=HTH-type transcriptional regulator SarZ;
DE   AltName: Full=Staphylococcal accessory regulator Z;
GN   Name=sarZ; OrderedLocusNames=SERP1979;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SarZ family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW52884.1; -; Genomic_DNA.
DR   RefSeq; WP_002438330.1; NC_002976.3.
DR   AlphaFoldDB; Q5HLK8; -.
DR   SMR; Q5HLK8; -.
DR   STRING; 176279.SERP1979; -.
DR   EnsemblBacteria; AAW52884; AAW52884; SERP1979.
DR   GeneID; 50017939; -.
DR   KEGG; ser:SERP1979; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_083287_3_2_9; -.
DR   OMA; VERCFLP; -.
DR   OrthoDB; 1626703at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..148
FT                   /note="HTH-type transcriptional regulator SarZ"
FT                   /id="PRO_0000284464"
FT   DOMAIN          9..139
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   148 AA;  17491 MW;  F3C407CF70C4C745 CRC64;
     MYVENSYLSK QLCFLFYVSS KEIIKKYTDY LKEYGLTYTG YIVLMAIEDD EKLNIKKLGE
     RVFLDSGTLT PLLKKLEKKN YVIRTREEQD ERNLQISLTE RGKDIQNVLS DISQSVFNEF
     NITQEETQNL VEDLQNFVTK NFDKTVEK