ID   SAS4_CAEBR              Reviewed;         761 AA.
AC   Q60JJ0; A8WKU9;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Spindle assembly abnormal protein 4;
GN   Name=sas-4; ORFNames=CBG24501;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for centrosome duplication. Plays a central role in
CC       determining centrosome size (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Note=Localizes to the centrosome
CC       throughout the cell cycle. Localizes to a tiny dot in the center of
CC       centrosome. Recruited to the centrosome once per cell cycle, at the
CC       time of organelle duplication and remains stably associated after (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; HE601095; CAP21094.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q60JJ0; -.
DR   SMR; Q60JJ0; -.
DR   STRING; 6238.CBG24501; -.
DR   PRIDE; Q60JJ0; -.
DR   EnsemblMetazoa; CBG24501.1; CBG24501.1; WBGene00042597.
DR   WormBase; CBG24501; CBP32937; WBGene00042597; Cbr-sas-4.
DR   eggNOG; ENOG502SYI4; Eukaryota.
DR   HOGENOM; CLU_018365_0_0_1; -.
DR   InParanoid; Q60JJ0; -.
DR   OMA; EFRLRWY; -.
DR   OrthoDB; 1111973at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Reference proteome.
FT   CHAIN           1..761
FT                   /note="Spindle assembly abnormal protein 4"
FT                   /id="PRO_0000097591"
FT   REGION          1..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          129..156
FT                   /evidence="ECO:0000255"
FT   COILED          326..464
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        10..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..507
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   761 AA;  87013 MW;  766FE80D4AEB4222 CRC64;
     MLPSENGDED QGSQKPKRAY LRKGEGTARF RMTRRSAPLT SSPAINLPRF TPTNSAPSSA
     RTIDSGIPHD DDTRPPTTAS LPLDQPSVLE SHDSGNRSES NERREEDNVE VVSAMQSYVP
     GDRSSSVLET CSKVSEEATQ LRAEADRITA QANFINSMKS VSITPSSYSS NISGPIYQST
     PKGSLRHDDL SDDPTFLPPP LVPPRNHSPQ TLSSLASSGS LDTPQARPLA GNRLNMMVQN
     EAQTGISLLN NPRRQPMLPA HHHPSQKENV PERKAPSEHV YDEPLQIQRP HRRNREEQRQ
     KHNLMLQLRD TIAHLDYASE CVWSTRKKQE EAYAKRMKEL EEDFESKMQM IQEDNTSEEE
     RLKRERRDIE RDRKILQKGI GEREKEHTQM IAKLREKLSN SESQNAKLRQ DKRAVEEKMK
     KFIEENEKLT KDLNRNRATC QRLEKHIKQL RTEKEKDDRE KEMFAKVAMN RKAAASGIAT
     GSAASSRLPS VSSLASSMKT GSTGKGRTVS FADDEPEEQT LEAGEETMQP EFIMRPYETK
     QSRFGTSTMY RDSIGETTRV TSTIANGLLF EYSNGDFRWM NRQNSVEIYR IAVDKSIIVN
     LLQYNISFIY FFQRQLEVWR PGNNTTLISV KRREVRTELH CENGTYYTEM FDRNGRYVTK
     DFCRPEVFKD IPPGSACSYR DGGTRYVEYT APEDFELVEP EYRLRWYQGK VMVCKIIKRP
     RCNEKTLRVQ VDVTTGSGIL EEVESQLKDG QSQKTTVFPW S